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Updated Values for Molecular Diagnosis for Highly Pathogenic Avian Influenza Virus
Department of Molecular Medical Research, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan
* Author to whom correspondence should be addressed.
Received: 20 July 2012; in revised form: 31 July 2012 / Accepted: 3 August 2012 / Published: 7 August 2012
Abstract: Highly pathogenic avian influenza (HPAI) viruses of the H5N1 strain pose a pandemic threat. H5N1 strain virus is extremely lethal and contagious for poultry. Even though mortality is 59% in infected humans, these viruses do not spread efficiently between humans. In 1997, an outbreak of H5N1 strain with human cases occurred in Hong Kong. This event highlighted the need for rapid identification and subtyping of influenza A viruses (IAV), not only to facilitate surveillance of the pandemic potential of avian IAV, but also to improve the control and treatment of infected patients. Molecular diagnosis has played a key role in the detection and typing of IAV in recent years, spurred by rapid advances in technologies for detection and characterization of viral RNAs and proteins. Such technologies, which include immunochromatography, quantitative real-time PCR, super high-speed real-time PCR, and isothermal DNA amplification, are expected to contribute to faster and easier diagnosis and typing of IAV.
Keywords: influenza virus; highly pathogenic avian influenza virus H5N1; molecular diagnosis
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Cite This Article
MDPI and ACS Style
Sakurai, A.; Shibasaki, F. Updated Values for Molecular Diagnosis for Highly Pathogenic Avian Influenza Virus. Viruses 2012, 4, 1235-1257.
Sakurai A, Shibasaki F. Updated Values for Molecular Diagnosis for Highly Pathogenic Avian Influenza Virus. Viruses. 2012; 4(8):1235-1257.
Sakurai, Akira; Shibasaki, Futoshi. 2012. "Updated Values for Molecular Diagnosis for Highly Pathogenic Avian Influenza Virus." Viruses 4, no. 8: 1235-1257.