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Viruses 2012, 4(8), 1258-1263; doi:10.3390/v4081258

The Role of Equine Herpesvirus Type 4 Glycoprotein K in Virus Replication

†,*  and
Department of Virology, Faculty of Veterinary Medicine, Zagazig University, Egypt Current address: Institute of Virology, Department of Veterinary Medicine, Free University of Berlin, Philippstrasse 13, Haus 18, 10115 Berlin, Germany.
* Author to whom correspondence should be addressed.
Received: 29 June 2012 / Revised: 31 July 2012 / Accepted: 3 August 2012 / Published: 7 August 2012
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Equine herpesvirus 4 (EHV-4) is an important equine pathogen that causes respiratory tract disease among horses worldwide. Glycoprotein K (gK) homologues have been identified in several alphaherpesviruses as a major player in virus entry, replication, and spread. In the present study, EHV-4 gK-deletion mutant has been generated by using bacterial artificial chromosome technology and Red mutagenesis to investigate the role of gK in EHV-4 replication. Our findings reported here show that gK is essential for virus replication in vitro and that the gK-negative strain was not able to be reconstituted in equine cells. It is noteworthy that these findings agree with the previously published study describing gK deletion in other alphaherpesviruses.
Keywords: EHV-4; BAC; gK EHV-4; BAC; gK
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Azab, W.; El-Sheikh, A. The Role of Equine Herpesvirus Type 4 Glycoprotein K in Virus Replication. Viruses 2012, 4, 1258-1263.

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