Next Article in Journal
Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions
Next Article in Special Issue
Arenavirus Variations Due to Host-Specific Adaptation
Previous Article in Journal
Molecular Adjuvant Ag85A Enhances Protection against Influenza A Virus in Mice Following DNA Vaccination
Previous Article in Special Issue
Multifunctional Nature of the Arenavirus RING Finger Protein Z
Article Menu

Export Article

Open AccessReview
Viruses 2012, 4(12), 3625-3646; doi:10.3390/v4123625

A Systems Biology Starter Kit for Arenaviruses

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90 033, USA
*
Author to whom correspondence should be addressed.
Received: 29 October 2012 / Revised: 28 November 2012 / Accepted: 5 December 2012 / Published: 11 December 2012
(This article belongs to the Special Issue Arenaviruses)
View Full-Text   |   Download PDF [802 KB, uploaded 12 May 2015]   |  

Abstract

Systems biology approaches in virology aim to integrate viral and host biological networks, and thus model the infection process. The growing availability of high-throughput “-omics” techniques and datasets, as well as the ever-increasing sophistication of in silico modeling tools, has resulted in a corresponding rise in the complexity of the analyses that can be performed. The present study seeks to review and organize published evidence regarding virus-host interactions for the arenaviruses, from alterations in the host proteome during infection, to reported protein-protein interactions. In this way, we hope to provide an overview of the interplay between arenaviruses and the host cell, and lay the foundations for complementing current arenavirus research with a systems-level approach. View Full-Text
Keywords: Arenavirus; interactome; infectome; virhostome; biological networks; systems biology; Lassa fever virus; Pichinde virus; lymphocytic choriomeningitis virus; Junin virus Arenavirus; interactome; infectome; virhostome; biological networks; systems biology; Lassa fever virus; Pichinde virus; lymphocytic choriomeningitis virus; Junin virus
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary materials

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Droniou-Bonzom, M.E.; Cannon, P.M. A Systems Biology Starter Kit for Arenaviruses. Viruses 2012, 4, 3625-3646.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top