Viruses 2012, 4(12), 3625-3646; doi:10.3390/v4123625
Review

A Systems Biology Starter Kit for Arenaviruses

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Received: 29 October 2012; in revised form: 28 November 2012 / Accepted: 5 December 2012 / Published: 11 December 2012
(This article belongs to the Special Issue Arenaviruses)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Systems biology approaches in virology aim to integrate viral and host biological networks, and thus model the infection process. The growing availability of high-throughput “-omics” techniques and datasets, as well as the ever-increasing sophistication of in silico modeling tools, has resulted in a corresponding rise in the complexity of the analyses that can be performed. The present study seeks to review and organize published evidence regarding virus-host interactions for the arenaviruses, from alterations in the host proteome during infection, to reported protein-protein interactions. In this way, we hope to provide an overview of the interplay between arenaviruses and the host cell, and lay the foundations for complementing current arenavirus research with a systems-level approach.
Keywords: Arenavirus; interactome; infectome; virhostome; biological networks; systems biology; Lassa fever virus; Pichinde virus; lymphocytic choriomeningitis virus; Junin virus
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MDPI and ACS Style

Droniou-Bonzom, M.E.; Cannon, P.M. A Systems Biology Starter Kit for Arenaviruses. Viruses 2012, 4, 3625-3646.

AMA Style

Droniou-Bonzom ME, Cannon PM. A Systems Biology Starter Kit for Arenaviruses. Viruses. 2012; 4(12):3625-3646.

Chicago/Turabian Style

Droniou-Bonzom, Magali E.; Cannon, Paula M. 2012. "A Systems Biology Starter Kit for Arenaviruses." Viruses 4, no. 12: 3625-3646.

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