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A Systems Biology Starter Kit for Arenaviruses
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, 2011 Zonal Avenue, Los Angeles, CA 90 033, USA
* Author to whom correspondence should be addressed.
Received: 29 October 2012; in revised form: 28 November 2012 / Accepted: 5 December 2012 / Published: 11 December 2012
Abstract: Systems biology approaches in virology aim to integrate viral and host biological networks, and thus model the infection process. The growing availability of high-throughput “-omics” techniques and datasets, as well as the ever-increasing sophistication of in silico modeling tools, has resulted in a corresponding rise in the complexity of the analyses that can be performed. The present study seeks to review and organize published evidence regarding virus-host interactions for the arenaviruses, from alterations in the host proteome during infection, to reported protein-protein interactions. In this way, we hope to provide an overview of the interplay between arenaviruses and the host cell, and lay the foundations for complementing current arenavirus research with a systems-level approach.
Keywords: Arenavirus; interactome; infectome; virhostome; biological networks; systems biology; Lassa fever virus; Pichinde virus; lymphocytic choriomeningitis virus; Junin virus
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Droniou-Bonzom, M.E.; Cannon, P.M. A Systems Biology Starter Kit for Arenaviruses. Viruses 2012, 4, 3625-3646.
Droniou-Bonzom ME, Cannon PM. A Systems Biology Starter Kit for Arenaviruses. Viruses. 2012; 4(12):3625-3646.
Droniou-Bonzom, Magali E.; Cannon, Paula M. 2012. "A Systems Biology Starter Kit for Arenaviruses." Viruses 4, no. 12: 3625-3646.