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Viruses 2012, 4(11), 2973-3011; doi:10.3390/v4112973
Review

Multifunctional Nature of the Arenavirus RING Finger Protein Z

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Received: 4 October 2012; in revised form: 4 November 2012 / Accepted: 5 November 2012 / Published: 9 November 2012
(This article belongs to the Special Issue Arenaviruses)
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Abstract: Arenaviruses are a family of enveloped negative-stranded RNA viruses that can cause severe human disease ranging from encephalitis symptoms to fulminant hemorrhagic fever. The bi‑segmented RNA genome encodes four polypeptides: the nucleoprotein NP, the surface glycoprotein GP, the polymerase L, and the RING finger protein Z. Although it is the smallest arenavirus protein with a length of 90 to 99 amino acids and a molecular weight of approx. 11 kDa, the Z protein has multiple functions in the viral life cycle including (i) regulation of viral RNA synthesis, (ii) orchestration of viral assembly and budding, (iii) interaction with host cell proteins, and (iv) interferon antagonism. In this review, we summarize our current understanding of the structural and functional role of the Z protein in the arenavirus replication cycle.
Keywords: Arenavirus; ESCRT; Lassa virus; Lymphocytic choriomeningitis virus; Junin virus; matrix protein; RING finger protein; virus assembly and budding; virus-host cell interaction; Z protein Arenavirus; ESCRT; Lassa virus; Lymphocytic choriomeningitis virus; Junin virus; matrix protein; RING finger protein; virus assembly and budding; virus-host cell interaction; Z protein
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fehling, S.K.; Lennartz, F.; Strecker, T. Multifunctional Nature of the Arenavirus RING Finger Protein Z. Viruses 2012, 4, 2973-3011.

AMA Style

Fehling SK, Lennartz F, Strecker T. Multifunctional Nature of the Arenavirus RING Finger Protein Z. Viruses. 2012; 4(11):2973-3011.

Chicago/Turabian Style

Fehling, Sarah K.; Lennartz, Frank; Strecker, Thomas. 2012. "Multifunctional Nature of the Arenavirus RING Finger Protein Z." Viruses 4, no. 11: 2973-3011.


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