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Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions
University of Mumbai and Department of Atomic Energy-Centre for Excellence in Basic Sciences, Health Centre Building, Vidyanagari, Kalina, Santacruz East, Mumbai 400098, India
Department of Microbiology and Immunology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
* Author to whom correspondence should be addressed.
Received: 7 November 2012; in revised form: 28 November 2012 / Accepted: 30 November 2012 / Published: 11 December 2012
Abstract: Detailed knowledge of the host-virus interactions that accompany filovirus entry into cells is expected to identify determinants of viral virulence and host range, and to yield targets for the development of antiviral therapeutics. While it is generally agreed that filovirus entry into the host cytoplasm requires viral internalization into acidic endosomal compartments and proteolytic cleavage of the envelope glycoprotein by endo/lysosomal cysteine proteases, our understanding of the specific endocytic pathways co-opted by filoviruses remains limited. This review addresses the current knowledge on cellular endocytic pathways implicated in filovirus entry, highlights the consensus as well as controversies, and discusses important remaining questions.
Keywords: filoviruses; viral entry; viral internalization; endocytosis; endocytic pathways; clathrin-mediated endocytosis; macropinocytosis; caveolae-mediated endocytosis
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Bhattacharyya, S.; Mulherkar, N.; Chandran, K. Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions. Viruses 2012, 4, 3647-3664.
Bhattacharyya S, Mulherkar N, Chandran K. Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions. Viruses. 2012; 4(12):3647-3664.
Bhattacharyya, Suchita; Mulherkar, Nirupama; Chandran, Kartik. 2012. "Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions." Viruses 4, no. 12: 3647-3664.