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Arenavirus Evasion of Host Anti-Viral Responses
Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
* Author to whom correspondence should be addressed.
Received: 21 September 2012; in revised form: 2 October 2012 / Accepted: 10 October 2012 / Published: 17 October 2012
Abstract: The innate response to infection by an Old World arenavirus is initiated and mediated by extracellular and intracellular receptors, and effector molecules. In response, the invading virus has evolved to inhibit these responses and create the best environment possible for replication and spread. Here, we will discuss both the host’s response to infection with data from human infection and lessons learned from animal models, as well as the multitude of ways the virus combats the resulting immune response. Finally, we will highlight recent work identifying TLR2 as an innate sensor for arenaviruses and how the TLR2-dependent response differs depending on the pathogenicity of the strain.
Keywords: arenavirus; innate immune response; immune evasion; TLR2
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Cite This Article
MDPI and ACS Style
Hayes, M.; Salvato, M. Arenavirus Evasion of Host Anti-Viral Responses. Viruses 2012, 4, 2182-2196.
Hayes M, Salvato M. Arenavirus Evasion of Host Anti-Viral Responses. Viruses. 2012; 4(10):2182-2196.
Hayes, Melissa; Salvato, Maria. 2012. "Arenavirus Evasion of Host Anti-Viral Responses." Viruses 4, no. 10: 2182-2196.