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• Grant, A
• Seregin, A
• Huang, C
• Kolokoltsova, O
• Brasier, A
• Peters, C
• Paessler, S
• [+] on Google Scholar
• Grant, A
• Seregin, A
• Huang, C
• Kolokoltsova, O
• Brasier, A
• Peters, C
• Paessler, S
• [+] on PubMed
• Grant, A
• Seregin, A
• Huang, C
• Kolokoltsova, O
• Brasier, A
• Peters, C
• Paessler, S

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Viruses 2012, 4(10), 2317-2339; doi:10.3390/v4102317

Review

Junín Virus Pathogenesis and Virus Replication

Ashley Grant ¹ , Alexey Seregin ¹ , Cheng Huang ¹ , Olga Kolokoltsova ¹ , Allan Brasier ² , Clarence Peters ¹  and Slobodan Paessler ^1,*

¹ Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA ² Institute for Translational Sciences, Department of Internal Medicine and Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, Texas, USA

* Author to whom correspondence should be addressed.

Received: 18 September 2012; in revised form: 2 October 2012 / Accepted: 10 October 2012 / Published: 19 October 2012

(This article belongs to the Special Issue Arenaviruses)

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Abstract: Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.

Keywords: arenavirus; Junín virus; pathogenesis

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