CiteULike
Facebook
Mendeley
Twitter
This article is- freely available
- re-usable
Viruses 2011, 3(9), 1681-1698; doi:10.3390/v3091681
Review
Viral Determinants of FeLV Infection and Pathogenesis: Lessons Learned from Analysis of a Natural Cohort
1
Department of Microbiology and Immunology, School of Medicine, Tulane University, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA
2
Tulane Cancer Center, School of Medicine, Tulane University, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA
* Author to whom correspondence should be addressed.
Received: 29 July 2011; in revised form: 31 August 2011 / Accepted: 1 September 2011 / Published: 9 September 2011
(This article belongs to the Special Issue Feline Retroviruses)
Download PDF Full-Text [371 KB, uploaded 9 September 2011 14:33 CEST]
Abstract: Detailed analysis has been performed over many years of a geographic and temporal cohort of cats naturally infected with feline leukemia virus (FeLV). Molecular analysis of FeLV present in the diseased tissues and application of those viruses to experimental systems has revealed unique isolates with distinctive disease potential, previously uncharacterized virus-receptor interactions, information about the role of recombinant viruses in disease induction, and novel viral and cellular oncogenes implicated in pathogenesis, among other findings. The studies have contributed to an understanding of the selective forces that lead to predominance of distinctive FeLV isolates and disease outcomes in a natural population.
Keywords: feline leukemia virus; lymphoma; pathogenesis; oncogenesis; long terminal repeat; surface glycoprotein
Article Statistics
Click here to load and display the download statistics.Cite This Article
MDPI and ACS Style
Bolin, L.L.; Levy, L.S. Viral Determinants of FeLV Infection and Pathogenesis: Lessons Learned from Analysis of a Natural Cohort. Viruses 2011, 3, 1681-1698.
AMA StyleBolin LL, Levy LS. Viral Determinants of FeLV Infection and Pathogenesis: Lessons Learned from Analysis of a Natural Cohort. Viruses. 2011; 3(9):1681-1698.
Chicago/Turabian StyleBolin, Lisa L.; Levy, Laura S. 2011. "Viral Determinants of FeLV Infection and Pathogenesis: Lessons Learned from Analysis of a Natural Cohort." Viruses 3, no. 9: 1681-1698.