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Viruses 2011, 3(7), 941-981; doi:10.3390/v3070941

Alphaherpesviruses and the Cytoskeleton in Neuronal Infections

Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Author to whom correspondence should be addressed.
Received: 11 May 2011 / Revised: 3 June 2011 / Accepted: 17 June 2011 / Published: 27 June 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
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Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.
Keywords: alphaherpesvirus; cytoskeleton; virus transport; neuroinvasion alphaherpesvirus; cytoskeleton; virus transport; neuroinvasion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zaichick, S.V.; Bohannon, K.P.; Smith, G.A. Alphaherpesviruses and the Cytoskeleton in Neuronal Infections. Viruses 2011, 3, 941-981.

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