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Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
* Author to whom correspondence should be addressed.
Received: 11 May 2011; in revised form: 3 June 2011 / Accepted: 17 June 2011 / Published: 27 June 2011
Abstract: Following infection of exposed peripheral tissues, neurotropic alphaherpesviruses invade nerve endings and deposit their DNA genomes into the nuclei of neurons resident in ganglia of the peripheral nervous system. The end result of these events is the establishment of a life-long latent infection. Neuroinvasion typically requires efficient viral transmission through a polarized epithelium followed by long-distance transport through the viscous axoplasm. These events are mediated by the recruitment of the cellular microtubule motor proteins to the intracellular viral particle and by alterations to the cytoskeletal architecture. The focus of this review is the interplay between neurotropic herpesviruses and the cytoskeleton.
Keywords: alphaherpesvirus; cytoskeleton; virus transport; neuroinvasion
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Cite This Article
MDPI and ACS Style
Zaichick, S.V.; Bohannon, K.P.; Smith, G.A. Alphaherpesviruses and the Cytoskeleton in Neuronal Infections. Viruses 2011, 3, 941-981.
Zaichick SV, Bohannon KP, Smith GA. Alphaherpesviruses and the Cytoskeleton in Neuronal Infections. Viruses. 2011; 3(7):941-981.
Zaichick, Sofia V.; Bohannon, Kevin P.; Smith, Gregory A. 2011. "Alphaherpesviruses and the Cytoskeleton in Neuronal Infections." Viruses 3, no. 7: 941-981.