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Alphaherpesviruses and the Cytoskeleton in Neuronal Infections
Viruses 2011, 3(7), 1015-1040; doi:10.3390/v3071015
Communication

Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type

Received: 2 February 2011; in revised form: 7 June 2011 / Accepted: 24 June 2011 / Published: 4 July 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
Download PDF [464 KB, uploaded 4 July 2011]
Abstract: Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.
Keywords: intermediate filament; herpesvirus; herpes simplex virus; varicella zoster virus; cytomegalovirus; Epstein-Barr virus; Kaposi’s sarcoma associated herpesvirus; cytoskeleton; infection intermediate filament; herpesvirus; herpes simplex virus; varicella zoster virus; cytomegalovirus; Epstein-Barr virus; Kaposi’s sarcoma associated herpesvirus; cytoskeleton; infection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hertel, L. Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type. Viruses 2011, 3, 1015-1040.

AMA Style

Hertel L. Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type. Viruses. 2011; 3(7):1015-1040.

Chicago/Turabian Style

Hertel, Laura. 2011. "Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type." Viruses 3, no. 7: 1015-1040.


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