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Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type
Center for Immunobiology and Vaccine Development, Children’s Hospital Oakland Research Institute, 5700 Martin Luther King Jr. Way, Oakland, CA 94609, USA
Received: 2 February 2011; in revised form: 7 June 2011 / Accepted: 24 June 2011 / Published: 4 July 2011
Abstract: Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.
Keywords: intermediate filament; herpesvirus; herpes simplex virus; varicella zoster virus; cytomegalovirus; Epstein-Barr virus; Kaposi’s sarcoma associated herpesvirus; cytoskeleton; infection
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Hertel, L. Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type. Viruses 2011, 3, 1015-1040.
Hertel L. Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type. Viruses. 2011; 3(7):1015-1040.
Hertel, Laura. 2011. "Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type." Viruses 3, no. 7: 1015-1040.