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Beclin-1 Targeting for Viral Immune Escape
Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Received: 23 June 2011; in revised form: 4 July 2011 / Accepted: 5 July 2011 / Published: 12 July 2011
Abstract: Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4+ T cells. Due to these protective functions during immune responses, several pathogens, including RNA and DNA viruses, have developed strategies to inhibit autophagosome generation or maturation. Interestingly, most of the respective viral proteins exert these functions via binding to Beclin-1, an essential macroautophagy protein that constitutes part of the phosphatidylinositol-3 kinase complexes that mark membranes for autophagosome generation and facilitate autophagosome fusion with lyososomes. The viruses that inhibit macroautophagy by this pathway include herpesviruses, HIV and influenza A virus. Inhibition either before or after autophagosome formation seems to benefit their viral replication by different mechanisms, which are discussed here.
Keywords: autophagy; influenza virus; HIV; HSV; KSHV; immunity; immune evasion
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MDPI and ACS Style
Münz, C. Beclin-1 Targeting for Viral Immune Escape. Viruses 2011, 3, 1166-1178.
Münz C. Beclin-1 Targeting for Viral Immune Escape. Viruses. 2011; 3(7):1166-1178.
Münz, Christian. 2011. "Beclin-1 Targeting for Viral Immune Escape." Viruses 3, no. 7: 1166-1178.