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Viruses 2011, 3(7), 1166-1178; doi:10.3390/v3071166

Beclin-1 Targeting for Viral Immune Escape

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
Received: 23 June 2011 / Revised: 4 July 2011 / Accepted: 5 July 2011 / Published: 12 July 2011
(This article belongs to the Special Issue Autophagy and Viruses)
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Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4+ T cells. Due to these protective functions during immune responses, several pathogens, including RNA and DNA viruses, have developed strategies to inhibit autophagosome generation or maturation. Interestingly, most of the respective viral proteins exert these functions via binding to Beclin-1, an essential macroautophagy protein that constitutes part of the phosphatidylinositol-3 kinase complexes that mark membranes for autophagosome generation and facilitate autophagosome fusion with lyososomes. The viruses that inhibit macroautophagy by this pathway include herpesviruses, HIV and influenza A virus. Inhibition either before or after autophagosome formation seems to benefit their viral replication by different mechanisms, which are discussed here.
Keywords: autophagy; influenza virus; HIV; HSV; KSHV; immunity; immune evasion autophagy; influenza virus; HIV; HSV; KSHV; immunity; immune evasion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Münz, C. Beclin-1 Targeting for Viral Immune Escape. Viruses 2011, 3, 1166-1178.

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