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Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Sint-Pietersnieuwstraat 25, B-9000 Ghent, Belgium
* Author to whom correspondence should be addressed.
Received: 31 January 2011; in revised form: 15 March 2011 / Accepted: 16 March 2011 / Published: 24 March 2011
Abstract: Herpesviruses constitute a very large and diverse family of DNA viruses, which can generally be subdivided in alpha-, beta- and gammaherpesvirus subfamilies. Increasing evidence indicates that many herpesviruses interact with cytoskeleton-regulating Rho GTPase signaling pathways during different phases of their replication cycle. Because of the large differences between herpesvirus subfamilies, the molecular mechanisms and specific consequences of individual herpesvirus interactions with Rho GTPase signaling may differ. However, some evolutionary distinct but similar general effects on Rho GTPase signaling and the cytoskeleton have also been reported. Examples of these include Rho GTPase-mediated nuclear translocation of virus during entry in a host cell and Rho GTPase-mediated viral cell-to-cell spread during later stages of infection. The current review gives an overview of both general and individual interactions of herpesviruses with Rho GTPase signaling.
Keywords: herpesvirus; Rho GTPases; actin; cytoskeleton
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Van den Broeke, C.; Favoreel, H.W. Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling. Viruses 2011, 3, 278-292.
Van den Broeke C, Favoreel HW. Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling. Viruses. 2011; 3(4):278-292.
Van den Broeke, Céline; Favoreel, Herman W. 2011. "Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling." Viruses 3, no. 4: 278-292.