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Paradoxical Interplay of Viral and Cellular Functions
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/ Nicolás Cabrera, 1, Cantoblanco, Madrid 28049, Spain
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona 08036, Spain
Received: 9 February 2011; in revised form: 3 March 2011 / Accepted: 7 March 2011 / Published: 15 March 2011
Abstract: Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens . The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.
Keywords: RNA virus; host-virus interaction; coevolution
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Domingo, E. Paradoxical Interplay of Viral and Cellular Functions. Viruses 2011, 3, 272-277.
Domingo E. Paradoxical Interplay of Viral and Cellular Functions. Viruses. 2011; 3(3):272-277.
Domingo, Esteban. 2011. "Paradoxical Interplay of Viral and Cellular Functions." Viruses 3, no. 3: 272-277.