Next Article in Journal
Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling
Previous Article in Journal
The Cytoskeleton in Papillomavirus Infection
Viruses 2011, 3(3), 272-277; doi:10.3390/v3030272
Commentary

Paradoxical Interplay of Viral and Cellular Functions

1,2
1 Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/ Nicolás Cabrera, 1, Cantoblanco, Madrid 28049, Spain 2 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona 08036, Spain
Received: 9 February 2011 / Revised: 3 March 2011 / Accepted: 7 March 2011 / Published: 15 March 2011
Download PDF [157 KB, uploaded 12 May 2015]

Abstract

Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens [1]. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.
Keywords: RNA virus; host-virus interaction; coevolution RNA virus; host-virus interaction; coevolution
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Domingo, E. Paradoxical Interplay of Viral and Cellular Functions. Viruses 2011, 3, 272-277.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert