Viruses 2011, 3(3), 272-277; doi:10.3390/v3030272

Paradoxical Interplay of Viral and Cellular Functions

Received: 9 February 2011; in revised form: 3 March 2011 / Accepted: 7 March 2011 / Published: 15 March 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens [1]. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.
Keywords: RNA virus; host-virus interaction; coevolution
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MDPI and ACS Style

Domingo, E. Paradoxical Interplay of Viral and Cellular Functions. Viruses 2011, 3, 272-277.

AMA Style

Domingo E. Paradoxical Interplay of Viral and Cellular Functions. Viruses. 2011; 3(3):272-277.

Chicago/Turabian Style

Domingo, Esteban. 2011. "Paradoxical Interplay of Viral and Cellular Functions." Viruses 3, no. 3: 272-277.

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