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Viruses 2011, 3(3), 272-277; doi:10.3390/v3030272

Paradoxical Interplay of Viral and Cellular Functions

1 Centro de Biología Molecular Severo Ochoa (CSIC-UAM), C/ Nicolás Cabrera, 1, Cantoblanco, Madrid 28049, Spain 2 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona 08036, Spain
Received: 9 February 2011 / Revised: 3 March 2011 / Accepted: 7 March 2011 / Published: 15 March 2011
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Some cellular editing functions can restrict the replication of some viruses but contribute to completion of the life cycle of others. A recent study has identified an isoform of the adenosine deaminase acting on RNA type 1 (ADAR 1) as required for embryogenesis, and as a restriction factor for a number of important RNA virus pathogens [1]. The dual implication of key cellular functions in the innate immunity against viruses, or, paradoxically, as mediators of virus replication is interpreted in the light of the concept of virus-host coevolution and tinkering proposed for general evolution by François Jacob decades ago.
Keywords: RNA virus; host-virus interaction; coevolution RNA virus; host-virus interaction; coevolution
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Domingo, E. Paradoxical Interplay of Viral and Cellular Functions. Viruses 2011, 3, 272-277.

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