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Viruses 2011, 3(4), 293-311; doi:10.3390/v3040293

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication

Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany
* Author to whom correspondence should be addressed.
Received: 2 February 2011 / Revised: 11 March 2011 / Accepted: 19 March 2011 / Published: 28 March 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
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The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells.
Keywords: HIV; actin cytoskeleton; entry; Nef; cofilin HIV; actin cytoskeleton; entry; Nef; cofilin
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Stolp, B.; Fackler, O.T. How HIV Takes Advantage of the Cytoskeleton in Entry and Replication. Viruses 2011, 3, 293-311.

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