Next Article in Journal
Efficient Sensing of Avian Influenza Viruses by Porcine Plasmacytoid Dendritic Cells
Next Article in Special Issue
Actin in Herpesvirus Infection
Previous Article in Journal / Special Issue
Actin’ up: Herpesvirus Interactions with Rho GTPase Signaling
Viruses 2011, 3(4), 293-311; doi:10.3390/v3040293

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication

Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany
* Author to whom correspondence should be addressed.
Received: 2 February 2011 / Revised: 11 March 2011 / Accepted: 19 March 2011 / Published: 28 March 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
Download PDF [474 KB, uploaded 12 May 2015]


The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells.
Keywords: HIV; actin cytoskeleton; entry; Nef; cofilin HIV; actin cytoskeleton; entry; Nef; cofilin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Stolp, B.; Fackler, O.T. How HIV Takes Advantage of the Cytoskeleton in Entry and Replication. Viruses 2011, 3, 293-311.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert