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Viruses 2011, 3(4), 293-311; doi:10.3390/v3040293
Review

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication

 and
*
Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany
* Author to whom correspondence should be addressed.
Received: 2 February 2011 / Revised: 11 March 2011 / Accepted: 19 March 2011 / Published: 28 March 2011
(This article belongs to the Special Issue Cytoskeleton in Viral Infections)
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Abstract

The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells.
Keywords: HIV; actin cytoskeleton; entry; Nef; cofilin HIV; actin cytoskeleton; entry; Nef; cofilin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Stolp, B.; Fackler, O.T. How HIV Takes Advantage of the Cytoskeleton in Entry and Replication. Viruses 2011, 3, 293-311.

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