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How HIV Takes Advantage of the Cytoskeleton in Entry and Replication
Department of Infectious Diseases, Virology, University Hospital Heidelberg, Im Neuenheimer Feld 324, D-69120 Heidelberg, Germany
* Author to whom correspondence should be addressed.
Received: 2 February 2011; in revised form: 11 March 2011 / Accepted: 19 March 2011 / Published: 28 March 2011
Abstract: The host cell cytoskeleton plays a key role in the life cycle of viral pathogens whose propagation depends on mandatory intracellular steps. Accordingly, also the human immunodeficiency virus type 1 (HIV-1) has evolved strategies to exploit and modulate in particular the actin cytoskeleton for its purposes. This review will recapitulate recent findings on how HIV-1 hijacks the cytoskeleton to facilitate entry into, transport within and egress from host cells as well as to commandeer communication of infected with uninfected bystander cells.
Keywords: HIV; actin cytoskeleton; entry; Nef; cofilin
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MDPI and ACS Style
Stolp, B.; Fackler, O.T. How HIV Takes Advantage of the Cytoskeleton in Entry and Replication. Viruses 2011, 3, 293-311.
Stolp B, Fackler OT. How HIV Takes Advantage of the Cytoskeleton in Entry and Replication. Viruses. 2011; 3(4):293-311.
Stolp, Bettina; Fackler, Oliver T. 2011. "How HIV Takes Advantage of the Cytoskeleton in Entry and Replication." Viruses 3, no. 4: 293-311.