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Viruses 2011, 3(3), 172-203; doi:10.3390/v3030172

Bacteriophage Assembly

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
* Author to whom correspondence should be addressed.
Received: 5 January 2011 / Revised: 9 February 2011 / Accepted: 14 February 2011 / Published: 25 February 2011
(This article belongs to the Special Issue Bacteriophage Assembly)
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Bacteriophages have been a model system to study assembly processes for over half a century. Formation of infectious phage particles involves specific protein-protein and protein-nucleic acid interactions, as well as large conformational changes of assembly precursors. The sequence and molecular mechanisms of phage assembly have been elucidated by a variety of methods. Differences and similarities of assembly processes in several different groups of bacteriophages are discussed in this review. The general principles of phage assembly are applicable to many macromolecular complexes.
Keywords: bacteriophage; assembly; macromolecular complex; genome packaging; maturation bacteriophage; assembly; macromolecular complex; genome packaging; maturation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Aksyuk, A.A.; Rossmann, M.G. Bacteriophage Assembly. Viruses 2011, 3, 172-203.

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