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Flavivirus Cell Entry and Membrane Fusion
Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
* Author to whom correspondence should be addressed.
Received: 19 January 2011; in revised form: 10 February 2011 / Accepted: 10 February 2011 / Published: 22 February 2011
(This article belongs to the Section Editorial
Abstract: Flaviviruses, such as dengue virus and West Nile virus, are enveloped viruses that infect cells through receptor-mediated endocytosis and fusion from within acidic endosomes. The cell entry process of flaviviruses is mediated by the viral E glycoprotein. This short review will address recent advances in the understanding of flavivirus cell entry with specific emphasis on the recent study of Zaitseva and coworkers, indicating that anionic lipids might play a crucial role in the fusion process of dengue virus .
Keywords: flavivirus; membrane fusion; anionic lipids; negatively charged lipids; cell entry; receptor; dengue; West Nile virus
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Smit, J.M.; Moesker, B.; Rodenhuis-Zybert, I.; Wilschut, J. Flavivirus Cell Entry and Membrane Fusion. Viruses 2011, 3, 160-171.
Smit JM, Moesker B, Rodenhuis-Zybert I, Wilschut J. Flavivirus Cell Entry and Membrane Fusion. Viruses. 2011; 3(2):160-171.
Smit, Jolanda M.; Moesker, Bastiaan; Rodenhuis-Zybert, Izabela; Wilschut, Jan. 2011. "Flavivirus Cell Entry and Membrane Fusion." Viruses 3, no. 2: 160-171.