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Viruses 2010, 2(8), 1704-1717; doi:10.3390/v2081704
Review

Dendritic Cells and HIV-1 Trans-Infection

Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Received: 22 July 2010 / Accepted: 9 August 2010 / Published: 17 August 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Abstract

Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious synapse. This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro and is thought to contribute to viral dissemination in vivo. This review outlines the recent data defining the mechanisms of trans-infection and provides a context for the potential contribution of trans-infection in HIV-1 disease.
Keywords: myeloid dendritic cell; C-type lectin receptor; antigen presentation; trans-infection; infectious synapse myeloid dendritic cell; C-type lectin receptor; antigen presentation; trans-infection; infectious synapse
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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McDonald, D. Dendritic Cells and HIV-1 Trans-Infection. Viruses 2010, 2, 1704-1717.

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