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Viruses 2010, 2(8), 1704-1717; doi:10.3390/v2081704

Dendritic Cells and HIV-1 Trans-Infection

Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
Received: 22 July 2010 / Accepted: 9 August 2010 / Published: 17 August 2010
(This article belongs to the Special Issue Transmission of Retroviruses across Virological Synapses)
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Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious synapse. This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro and is thought to contribute to viral dissemination in vivo. This review outlines the recent data defining the mechanisms of trans-infection and provides a context for the potential contribution of trans-infection in HIV-1 disease.
Keywords: myeloid dendritic cell; C-type lectin receptor; antigen presentation; trans-infection; infectious synapse myeloid dendritic cell; C-type lectin receptor; antigen presentation; trans-infection; infectious synapse
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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McDonald, D. Dendritic Cells and HIV-1 Trans-Infection. Viruses 2010, 2, 1704-1717.

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