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Dendritic Cells and HIV-1 Trans-Infection
AbstractDendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse. Dendritic cells can also transfer intact, infectious HIV-1 to CD4 T cells through an analogous structure, the infectious synapse. This replication independent mode of HIV-1 transmission, known as trans-infection, greatly increases T cell infection in vitro and is thought to contribute to viral dissemination in vivo. This review outlines the recent data defining the mechanisms of trans-infection and provides a context for the potential contribution of trans-infection in HIV-1 disease.
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McDonald, D. Dendritic Cells and HIV-1 Trans-Infection. Viruses 2010, 2, 1704-1717.View more citation formats
McDonald D. Dendritic Cells and HIV-1 Trans-Infection. Viruses. 2010; 2(8):1704-1717.Chicago/Turabian Style
McDonald, David. 2010. "Dendritic Cells and HIV-1 Trans-Infection." Viruses 2, no. 8: 1704-1717.