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Innate Antiviral Immune Responses to Hepatitis B Virus
INSERM, U871, Molecular Physiopathology and New Treatment of Viral Hepatitis, 151 Cours Albert Thomas, 69003 Lyon, France
Université de Lyon, UCBL, and IFR62 Lyon Est, 69008 Lyon, France
Hospices Civils de Lyon (HCL), Hôtel Dieu Hospital, 69002 Lyon, France
Present address: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstas.30, D-81675 München, Germany
* Author to whom correspondence should be addressed.
Received: 4 June 2010; in revised form: 22 June 2010 / Accepted: 1 July 2010 / Published: 5 July 2010
Abstract: Hepatitis B virus (HBV) is a major cause of acute and chronic hepatitis in humans. As HBV itself is currently viewed as a non-cytopathic virus, the liver pathology associated with hepatitis B is mainly thought to be due to immune responses directed against HBV antigens. The outcome of HBV infection is the result of complex interactions between replicating HBV and the immune system. While the role of the adaptive immune response in the resolution of HBV infection is well understood, the contribution of innate immune mechanisms remains to be clearly defined. The innate immune system represents the first line of defense against viral infection, but its role has been difficult to analyze in humans due to late diagnosis of HBV infection. In this review, we discuss recent advances in the field of innate immunity to HBV infection.
Keywords: Hepatitis B virus; innate immunity; cytokines; pathogenesis
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Ait-goughoulte, M.; Lucifora, J.; Zoulim, F.; Durantel, D. Innate Antiviral Immune Responses to Hepatitis B Virus. Viruses 2010, 2, 1394-1410.
Ait-goughoulte M, Lucifora J, Zoulim F, Durantel D. Innate Antiviral Immune Responses to Hepatitis B Virus. Viruses. 2010; 2(7):1394-1410.
Ait-goughoulte, Malika; Lucifora, Julie; Zoulim, Fabien; Durantel, David. 2010. "Innate Antiviral Immune Responses to Hepatitis B Virus." Viruses 2, no. 7: 1394-1410.