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Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections
Viruses 2010, 2(7), 1394-1410; doi:10.3390/v2071394

Innate Antiviral Immune Responses to Hepatitis B Virus

1 INSERM, U871, Molecular Physiopathology and New Treatment of Viral Hepatitis, 151 Cours Albert Thomas, 69003 Lyon, France 2 Université de Lyon, UCBL, and IFR62 Lyon Est, 69008 Lyon, France 3 Hospices Civils de Lyon (HCL), Hôtel Dieu Hospital, 69002 Lyon, France Present address: Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Trogerstas.30, D-81675 München, Germany
* Author to whom correspondence should be addressed.
Received: 4 June 2010 / Revised: 22 June 2010 / Accepted: 1 July 2010 / Published: 5 July 2010
(This article belongs to the Special Issue Hepatitis Viruses)
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Hepatitis B virus (HBV) is a major cause of acute and chronic hepatitis in humans. As HBV itself is currently viewed as a non-cytopathic virus, the liver pathology associated with hepatitis B is mainly thought to be due to immune responses directed against HBV antigens. The outcome of HBV infection is the result of complex interactions between replicating HBV and the immune system. While the role of the adaptive immune response in the resolution of HBV infection is well understood, the contribution of innate immune mechanisms remains to be clearly defined. The innate immune system represents the first line of defense against viral infection, but its role has been difficult to analyze in humans due to late diagnosis of HBV infection. In this review, we discuss recent advances in the field of innate immunity to HBV infection.
Keywords: Hepatitis B virus; innate immunity; cytokines; pathogenesis Hepatitis B virus; innate immunity; cytokines; pathogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ait-goughoulte, M.; Lucifora, J.; Zoulim, F.; Durantel, D. Innate Antiviral Immune Responses to Hepatitis B Virus. Viruses 2010, 2, 1394-1410.

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