Next Article in Journal
The Revolution in Viral Genomics as Exemplified by the Bioinformatic Analysis of Human Adenoviruses
Next Article in Special Issue
Role of Gag in HIV Resistance to Protease Inhibitors
Previous Article in Journal
Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate
Previous Article in Special Issue
HIV-1 Entry, Inhibitors, and Resistance
Viruses 2010, 2(7), 1347-1366; doi:10.3390/v2071347

Resistance to Integrase Inhibitors

 and *
Received: 27 April 2010 / Revised: 17 June 2010 / Accepted: 19 June 2010 / Published: 25 June 2010
(This article belongs to the Special Issue HIV Drug Resistance 2010)
View Full-Text   |   Download PDF [1107 KB, updated 28 June 2010; original version uploaded 25 June 2010]   |   Browse Figures
Abstract: Integrase (IN) is a clinically validated target for the treatment of human immunodeficiency virus infections and raltegravir exhibits remarkable clinical activity. The next most advanced IN inhibitor is elvitegravir. However, mutant viruses lead to treatment failure and mutations within the IN coding sequence appear to confer cross-resistance. The characterization of those mutations is critical for the development of second generation IN inhibitors to overcome resistance. This review focuses on IN resistance based on structural and biochemical data, and on the role of the IN flexible loop i.e., between residues G140-G149 in drug action and resistance.
Keywords: AIDS; HIV-1 integrase; Raltegravir; Elvitegravir; GSK-1349572; GSK-1265744; interfacial inhibitors; resistance AIDS; HIV-1 integrase; Raltegravir; Elvitegravir; GSK-1349572; GSK-1265744; interfacial inhibitors; resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Métifiot, M.; Marchand, C.; Maddali, K.; Pommier, Y. Resistance to Integrase Inhibitors. Viruses 2010, 2, 1347-1366.

AMA Style

Métifiot M, Marchand C, Maddali K, Pommier Y. Resistance to Integrase Inhibitors. Viruses. 2010; 2(7):1347-1366.

Chicago/Turabian Style

Métifiot, Mathieu; Marchand, Christophe; Maddali, Kasthuraiah; Pommier, Yves. 2010. "Resistance to Integrase Inhibitors." Viruses 2, no. 7: 1347-1366.

Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert