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Viruses 2010, 2(2), 413-434; doi:10.3390/v2020413
Review

RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis

Received: 31 August 2009 / Revised: 25 January 2010 / Accepted: 27 January 2010 / Published: 29 January 2010
(This article belongs to the Special Issue Influenza: Pandemics and Vaccinations)
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Abstract

RNA replicons are derived from either positive- or negative-strand RNA viruses. They represent disabled virus vectors that are not only avirulent, but also unable to revert to virulence. Due to autonomous RNA replication, RNA replicons are able to drive high level, cytosolic expression of recombinant antigens stimulating both the humoral and the cellular branch of the immune system. This review provides an update on the available literature covering influenza virus vaccines based on RNA replicons. The pros and cons of these vaccine strategies will be discussed and future perspectives disclosed.
Keywords: RNA replicon; vaccine; biosafety; cellular immunity; mucosal immunity; heterosubtypic immunity; alphavirus; vesicular stomatitis virus RNA replicon; vaccine; biosafety; cellular immunity; mucosal immunity; heterosubtypic immunity; alphavirus; vesicular stomatitis virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zimmer, G. RNA Replicons - A New Approach for Influenza Virus Immunoprophylaxis. Viruses 2010, 2, 413-434.

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