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Serotype Chimeric Human Adenoviruses for Cancer GeneTherapy
Cancer Gene Therapy Group, Molecular Cancer Biology Program, University of Helsinki, P.O. Box 63, 00014 University of Helsinki, Finland
HUSLAB , Helsinki University Central Hospital, P.O. Box 100, 00029 HUS, Helsinki, Finland
Haartman Institute & Transplantation Laboratory, University of Helsinki, P.O. Box 21, 00014 University of Helsinki, Finland
Finnish Institute for Molecular Medicine, University of Helsinki, P.O.Box 20, 00014 University of Helsinki, Finland
* Author to whom correspondence should be addressed.
Received: 18 June 2010; in revised form: 16 August 2010 / Accepted: 22 September 2010 / Published: 30 September 2010
Abstract: Cancer gene therapy consists of numerous approaches where the common denominator is utilization of vectors for achieving therapeutic effect. A particularly potent embodiment of the approach is virotherapy, in which the replication potential of an oncolytic virus is directed towards tumor cells to cause lysis, while normal cells are spared. Importantly, the therapeutic effect of the initial viral load is amplified through viral replication cycles and production of progeny virions. All cancer gene therapy approaches rely on a sufficient level of delivery of the anticancer agent into target cells. Thus,enhancement of delivery to target cells, and reduction of delivery to non-target cells, in an approach called transductional targeting, is attractive. Both genetic and non-genetic retargeting strategies have been utilized. However, in the context of oncolytic viruses, it is beneficial to have the specific modification included in progeny virions and hence genetic modification may be preferable. Serotype chimerism utilizes serotype specific differences in receptor usage, liver tropism and seroprevalence in order to gain enhanced infection of target tissue. This review will focus on serotype chimeric adenoviruses for cancer gene therapy applications.
Keywords: adenoviruses; serotype chimerism; neutralizing antibodies; tumor targeting; liver detargeting
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MDPI and ACS Style
Ranki, T.; Hemminki, A. Serotype Chimeric Human Adenoviruses for Cancer GeneTherapy. Viruses 2010, 2, 2196-2212.
Ranki T, Hemminki A. Serotype Chimeric Human Adenoviruses for Cancer GeneTherapy. Viruses. 2010; 2(10):2196-2212.
Ranki, Tuuli; Hemminki, Akseli. 2010. "Serotype Chimeric Human Adenoviruses for Cancer GeneTherapy." Viruses 2, no. 10: 2196-2212.