Viruses 2010, 2(10), 2169-2195; doi:10.3390/v2102169
Review

Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B

1 McGill University, Department of Microbiology and Immunology, 3775 University Room D6, Montreal Quebec, H3A2B4, Canada 2 McGill University, Department of Biochemistry, 3775 University Room D6, Montreal Quebec, H3A2B4, Canada
* Author to whom correspondence should be addressed.
Received: 29 July 2010; in revised form: 6 September 2010 / Accepted: 6 September 2010 / Published: 28 September 2010
(This article belongs to the Special Issue Antivirals Against Hepatitis C Virus)
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Abstract: More than 20 years after the identification of the hepatitis C virus (HCV) as a novel human pathogen, the only approved treatment remains a combination of pegylated interferon-α and ribavirin. This rather non-specific therapy is associated with severe side effects and by far not everyone benefits from treatment. Recently, progress has been made in the development of specifically targeted antiviral therapy for HCV (STAT-C). A major target for such direct acting antivirals (DAAs) is the HCV RNA-dependent RNA polymerase or non-structural protein 5B (NS5B), which is essential for viral replication. This review will examine the current state of development of inhibitors targeting the polymerase and issues such as the emergence of antiviral resistance during treatment, as well as strategies to address this problem.
Keywords: HCV NS5B polymerase inhibitors; drug resistance; viral fitness; genetic barrier

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MDPI and ACS Style

Powdrill, M.H.; Bernatchez, J.A.; Götte, M. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses 2010, 2, 2169-2195.

AMA Style

Powdrill MH, Bernatchez JA, Götte M. Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B. Viruses. 2010; 2(10):2169-2195.

Chicago/Turabian Style

Powdrill, Megan H.; Bernatchez, Jean A.; Götte, Matthias. 2010. "Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B." Viruses 2, no. 10: 2169-2195.

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