Viruses 2010, 2(1), 244-261; doi:10.3390/v2010244
Review

Virus Infection Recognition and Early Innate Responses to Non-Enveloped Viral Vectors

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Received: 20 October 2009; in revised form: 13 January 2010 / Accepted: 14 January 2010 / Published: 19 January 2010
(This article belongs to the Special Issue Novel Viral Vector Systems for Gene Therapy)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Numerous human genetic and acquired diseases could be corrected or ameliorated if viruses are harnessed to safely and effectively deliver therapeutic genes to diseased cells and tissues in vivo. Innate immune and inflammatory response represents one of the key stumbling blocks during the development of viral-based therapies. In this review, current data on the early innate immune responses to viruses and to the most commonly used gene therapy vectors (using adenovirus and adeno-associated virus) will be discussed. Recent findings in the field may help develop new approaches to moderate these innate immune anti-viral responses and thus improve the safety of viral vectors for human gene therapy applications.
Keywords: virus vectors; innate immunity; inflammation
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MDPI and ACS Style

Shayakhmetov, D.M. Virus Infection Recognition and Early Innate Responses to Non-Enveloped Viral Vectors. Viruses 2010, 2, 244-261.

AMA Style

Shayakhmetov DM. Virus Infection Recognition and Early Innate Responses to Non-Enveloped Viral Vectors. Viruses. 2010; 2(1):244-261.

Chicago/Turabian Style

Shayakhmetov, Dmitry M. 2010. "Virus Infection Recognition and Early Innate Responses to Non-Enveloped Viral Vectors." Viruses 2, no. 1: 244-261.


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