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Interaction of Host Cellular Proteins with Components of the Hepatitis Delta Virus
Department of Biochemistry, Microbiology & Immunology, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada
Canadian Blood Services, 1800 Alta Vista Drive, Ottawa, Ontario, K1G 4J5, Canada
* Author to whom correspondence should be addressed.
Received: 29 October 2009; in revised form: 13 January 2010 / Accepted: 14 January 2010 / Published: 18 January 2010
Abstract: The hepatitis delta virus (HDV) is the smallest known RNA pathogen capable of propagation in the human host and causes substantial global morbidity and mortality. Due to its small size and limited protein coding capacity, HDV is exquisitely reliant upon host cellular proteins to facilitate its transcription and replication. Remarkably, HDV does not encode an RNA-dependent RNA polymerase which is traditionally required to catalyze RNA-templated RNA synthesis. Furthermore, HDV lacks enzymes responsible for post-transcriptional and -translational modification, processes which are integral to the HDV life cycle. This review summarizes the known HDV-interacting proteins and discusses their significance in HDV biology.
Keywords: hepatitis delta virus (HDV); delta antigens (HDAg-S and HDAg-L); DNA-dependant RNA polymerase (RNAP)
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Greco-Stewart, V.; Pelchat, M. Interaction of Host Cellular Proteins with Components of the Hepatitis Delta Virus. Viruses 2010, 2, 189-212.
Greco-Stewart V, Pelchat M. Interaction of Host Cellular Proteins with Components of the Hepatitis Delta Virus. Viruses. 2010; 2(1):189-212.
Greco-Stewart, Valerie; Pelchat, Martin. 2010. "Interaction of Host Cellular Proteins with Components of the Hepatitis Delta Virus." Viruses 2, no. 1: 189-212.