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Viruses 2010, 2(1), 131-146; doi:10.3390/v2010131
Review

RNA Editing and its Control in Hepatitis Delta Virus Replication

,
 and
*
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC 20007, USA
* Author to whom correspondence should be addressed.
Received: 7 December 2009 / Revised: 31 December 2009 / Accepted: 5 January 2009 / Published: 12 January 2010
(This article belongs to the Special Issue Subviral RNAs)
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Abstract

The hepatitis delta virus genome is a small circular RNA, similar to viroids. Although HDV contains a gene, the protein produced (HDAg) is encoded by less than half the genome and possesses no RNA polymerase activity. Because of this limited coding capacity, HDV relies heavily on host functions and on structural features of the viral RNA—very much like viroids. The virus’ use of host RNA editing activity to produce two functionally distinct forms of HDAg is a particularly good example of this reliance. This review covers the mechanisms and control of RNA editing in the HDV replication cycle.
Keywords: hepatitis delta virus; RNA editing; hepatitis delta antigen; ADAR1; RNA structure; RNA structural dynamics; RNA-protein interactions hepatitis delta virus; RNA editing; hepatitis delta antigen; ADAR1; RNA structure; RNA structural dynamics; RNA-protein interactions
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, R.; Linnstaedt, S.D.; Casey, J.L. RNA Editing and its Control in Hepatitis Delta Virus Replication. Viruses 2010, 2, 131-146.

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