Next Article in Journal
The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses
Next Article in Special Issue
Chondrocytes Contribute to Alphaviral Disease Pathogenesis as a Source of Virus Replication and Soluble Factor Production
Previous Article in Journal
Impact of Mutations in the Hemagglutinin of H10N7 Viruses Isolated from Seals on Virus Replication in Avian and Human Cells
Previous Article in Special Issue
Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Viruses 2018, 10(2), 84; https://doi.org/10.3390/v10020084

Mosquitoes as Suitable Vectors for Alphaviruses

Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, QLD 4215, Australia
*
Author to whom correspondence should be addressed.
Received: 8 January 2018 / Revised: 7 February 2018 / Accepted: 8 February 2018 / Published: 14 February 2018
(This article belongs to the Special Issue Advances in Alphavirus Research)
View Full-Text   |   Download PDF [1315 KB, uploaded 14 February 2018]   |  

Abstract

Alphaviruses are arthropod-borne viruses and are predominantly transmitted via mosquito vectors. This vector preference by alphaviruses raises the important question of the determinants that contribute to vector competence. There are several tissue barriers of the mosquito that the virus must overcome in order to establish a productive infection. Of importance are the midgut, basal lamina and the salivary glands. Infection of the salivary glands is crucial for virus transmission during the mosquito’s subsequent bloodfeed. Other factors that may contribute to vector competence include the microflora and parasites present in the mosquito, environmental conditions, the molecular determinants of the virus to adapt to the vector, as well as the effect of co-infection with other viruses. Though mosquito innate immunity is a contributing factor to vector competence, it will not be discussed in this review. Detailed understanding of these factors will be instrumental in minimising transmission of alphaviral diseases. View Full-Text
Keywords: arbovirus; vector competence; mosquito; infection; barriers; parasites; Wolbachia; microfilaria arbovirus; vector competence; mosquito; infection; barriers; parasites; Wolbachia; microfilaria
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Lim, E.X.Y.; Lee, W.S.; Madzokere, E.T.; Herrero, L.J. Mosquitoes as Suitable Vectors for Alphaviruses. Viruses 2018, 10, 84.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top