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Viruses 2018, 10(2), 71; https://doi.org/10.3390/v10020071

Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development

1
Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore
2
School of Biological Sciences, Nanyang Technological University, Singapore 636921, Singapore
3
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore
4
Institute of Infection and Global Health, University of Liverpool, Liverpool L69 7BE, UK
*
Author to whom correspondence should be addressed.
Received: 7 January 2018 / Revised: 2 February 2018 / Accepted: 6 February 2018 / Published: 9 February 2018
(This article belongs to the Special Issue Advances in Alphavirus Research)
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Abstract

Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available. The re-emergence of alphaviruses in Asia, Europe, and the Americas over the last decade, including chikungunya and o’nyong’nyong viruses, have intensified the search for selective inhibitors. In this review, we highlight key molecular determinants within the alphavirus replication complex that have been identified as viral targets, focusing on their structure and functionality in viral dissemination. We also summarize recent structural data of these viral targets and discuss how these could serve as templates to facilitate structure-based drug design and development of small molecule inhibitors. View Full-Text
Keywords: alphavirus replication; nonstructural protein; protease inhibitors alphavirus replication; nonstructural protein; protease inhibitors
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Abu Bakar, F.; Ng, L.F.P. Nonstructural Proteins of Alphavirus—Potential Targets for Drug Development. Viruses 2018, 10, 71.

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