Innate and Adaptive Immune Responses to Herpes Simplex Virus

doi:10.3390/v1030979

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Viruses 2009, 1(3), 979-1002; doi:10.3390/v1030979

Review

Innate and Adaptive Immune Responses to Herpes Simplex Virus

Tracy Chew¹, Kathryne E. Taylor² and Karen L. Mossman^1,2,*

¹ Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada ² Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

* Author to whom correspondence should be addressed.

Received: 30 July 2009; in revised form: 13 November 2009 / Accepted: 16 November 2009 / Published: 18 November 2009

(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)

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Abstract: Immune responses against HSV-1 and HSV-2 are complex and involve a delicate interplay between innate signaling pathways and adaptive immune responses. The innate response to HSV involves the induction of type I IFN, whose role in protection against disease is well characterized in vitro and in vivo. Cell types such as NK cells and pDCs contribute to innate anti-HSV responses in vivo. Finally, the adaptive response includes both humoral and cellular components that play important roles in antiviral control and latency. This review summarizes the innate and adaptive effectors that contribute to susceptibility, immune control and pathogenesis of HSV, and highlights the delicate interplay between these two important arms of immunity.

Keywords: Herpes Simplex virus (HSV); innate immunity; antiviral signaling; type I interferon (IFN); Natural killer (NK) cells; plasmacytoid dendritic cells (pDCs); adaptive immunity

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MDPI and ACS Style

Chew, T.; Taylor, K.E.; Mossman, K.L. Innate and Adaptive Immune Responses to Herpes Simplex Virus. Viruses 2009, 1, 979-1002.

AMA Style

Chew T., Taylor K.E., Mossman K.L. Innate and Adaptive Immune Responses to Herpes Simplex Virus. Viruses. 2009; 1(3):979-1002.

Chicago/Turabian Style

Chew, Tracy; Taylor, Kathryne E.; Mossman, Karen L. 2009. "Innate and Adaptive Immune Responses to Herpes Simplex Virus." Viruses 1, no. 3: 979-1002.

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