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Viruses 2009, 1(3), 939-964; doi:10.3390/v1030939
Review

Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections

Received: 24 July 2009 / Revised: 11 October 2009 / Accepted: 16 November 2009 / Published: 18 November 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)
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Abstract

One of the most common viral infections in humans is caused by herpes simplex virus (HSV). It can easily be treated with nucleoside analogues (e.g., acyclovir), but resistant strains are on the rise. Naturally occurring antimicrobial peptides have been demonstrated to possess antiviral activity against HSV. New evidence has also indicated that these host defence peptides are able to selectively stimulate the innate immune system to fight of infections. This review will focus on the anti-HSV activity of such peptides (both natural and synthetic), describe their mode of action and their clinical potential.
Keywords: cationic host defence peptides; antiviral therapy; herpes; antimicrobial peptides; innate defense regulators; immune stimulation cationic host defence peptides; antiviral therapy; herpes; antimicrobial peptides; innate defense regulators; immune stimulation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jenssen, H. Therapeutic Approaches Using Host Defence Peptides to Tackle Herpes Virus Infections. Viruses 2009, 1, 939-964.

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