Next Article in Journal / Special Issue
Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
Previous Article in Journal
A(H5N1) Virus Evolution in South East Asia
Previous Article in Special Issue
Regulation of Innate Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0)
Article Menu

Export Article

Open AccessReview
Viruses 2009, 1(3), 362-382; doi:10.3390/v1030362

The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors

Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA 94143, USA
*
Author to whom correspondence should be addressed.
Received: 14 August 2009 / Revised: 13 October 2009 / Accepted: 13 October 2009 / Published: 13 October 2009
(This article belongs to the Special Issue Antiviral Responses to Herpes Viruses)

Abstract

During the co-evolution of cytomegalovirus (CMV) and natural killer (NK) cells, each has evolved specific tactics in an attempt to prevail. CMV has evolved multiple immune evasion mechanisms to avoid detection by NK cells and other immune cells, leading to chronic infection. Meanwhile, the host has evolved virus-specific receptors to counter these evasion strategies. The natural selection of viral genes and host receptors allows us to observe a unique molecular example of "survival of the fittest", as virus and immune cells try to out-maneuver one another or for the virus to achieve détente for optimal dissemination in the population.
Keywords: NK cells; cytomegalovirus; evolution NK cells; cytomegalovirus; evolution
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sun, J.C.; Lanier, L.L. The Natural Selection of Herpesviruses and Virus-Specific NK Cell Receptors. Viruses 2009, 1, 362-382.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top