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Viruses 2009, 1(3), 335-361; doi:10.3390/v1030335

A(H5N1) Virus Evolution in South East Asia

1, 1
1 Institut Pasteur du Cambodge, Virology Unit, 5 Monivong boulevard, PO Box 983, Phnom Penh, Cambodia 2 National Veterinary Research Institute (NaVRI)/ Phum Trea, Sals Street # 371, Phnom Penh, Cambodia
* Author to whom correspondence should be addressed.
Received: 6 July 2009 / Revised: 2 September 2009 / Accepted: 2 October 2009 / Published: 6 October 2009
(This article belongs to the Special Issue Influenza: Pandemics and Vaccinations)
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Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is an ongoing public health and socio-economic challenge, particularly in South East Asia. H5N1 is now endemic in poultry in many countries, and represents a major pandemic threat. Here, we describe the evolution of H5N1 virus in South East Asia, the reassortment events leading to high genetic diversity in the region, and factors responsible for virus spread. The virus has evolved with genetic variations affecting virulence, drug-resistance, and adaptation to new host species. The constant surveillance of these changes is of primary importance in the global efforts of the scientific community.
Keywords: avian influenza; H5N1 virus; evolution; South East Asia avian influenza; H5N1 virus; evolution; South East Asia
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gutiérrez, R.A.; Naughtin, M.J.; Horm, S.V.; San, S.; Buchy, P. A(H5N1) Virus Evolution in South East Asia. Viruses 2009, 1, 335-361.

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