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Viruses 2009, 1(3), 335-361; doi:10.3390/v1030335
Review
A(H5N1) Virus Evolution in South East Asia
Ramona Alikiiteaga Gutiérrez 1 , Monica Jane Naughtin 1 
, Srey Viseth Horm 1 , Sorn San 2 and Philippe Buchy 1,*
, Srey Viseth Horm 1 , Sorn San 2 and Philippe Buchy 1,*
1
Institut Pasteur du Cambodge, Virology Unit, 5 Monivong boulevard, PO Box 983, Phnom Penh, Cambodia
2
National Veterinary Research Institute (NaVRI)/ Phum Trea, Sals Street # 371, Phnom Penh, Cambodia
* Author to whom correspondence should be addressed.
Received: 6 July 2009; in revised form: 2 September 2009 / Accepted: 2 October 2009 / Published: 6 October 2009
(This article belongs to the Special Issue Influenza: Pandemics and Vaccinations)
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Abstract: Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is an ongoing public health and socio-economic challenge, particularly in South East Asia. H5N1 is now endemic in poultry in many countries, and represents a major pandemic threat. Here, we describe the evolution of H5N1 virus in South East Asia, the reassortment events leading to high genetic diversity in the region, and factors responsible for virus spread. The virus has evolved with genetic variations affecting virulence, drug-resistance, and adaptation to new host species. The constant surveillance of these changes is of primary importance in the global efforts of the scientific community.
Keywords: avian influenza; H5N1 virus; evolution; South East Asia
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MDPI and ACS Style
Gutiérrez, R.A.; Naughtin, M.J.; Horm, S.V.; San, S.; Buchy, P. A(H5N1) Virus Evolution in South East Asia. Viruses 2009, 1, 335-361.
AMA StyleGutiérrez RA, Naughtin MJ, Horm SV, San S, Buchy P. A(H5N1) Virus Evolution in South East Asia. Viruses. 2009; 1(3):335-361.
Chicago/Turabian StyleGutiérrez, Ramona A.; Naughtin, Monica J.; Horm, Srey V.; San, Sorn; Buchy, Philippe. 2009. "A(H5N1) Virus Evolution in South East Asia." Viruses 1, no. 3: 335-361.