Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections
AbstractType-I interferons (IFN-I) are cytokines essential for vertebrate antiviral defense, including against herpesviruses. IFN-I have potent direct antiviral activities and also mediate a multiplicity of immunoregulatory functions, which can either promote or dampen antiviral adaptive immune responses. Plasmacytoid dendritic cells (pDCs) are the professional producers of IFN-I in response to many viruses, including all of the herpesviruses tested. There is strong evidence that pDCs could play a major role in the initial orchestration of both innate and adaptive antiviral immune responses. Depending on their activation pattern, pDC responses may be either protective or detrimental to the host. Here, we summarize and discuss current knowledge regarding pDC implication in the physiopathology of mouse and human herpesvirus infections, and we discuss how pDC functions could be manipulated in immunotherapeutic settings to promote health over disease.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Baranek, T.; Zucchini, N.; Dalod, M. Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections. Viruses 2009, 1, 383-419.
Baranek T, Zucchini N, Dalod M. Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections. Viruses. 2009; 1(3):383-419.Chicago/Turabian Style
Baranek, Thomas; Zucchini, Nicolas; Dalod, Marc. 2009. "Plasmacytoid Dendritic Cells and the Control of Herpesvirus Infections." Viruses 1, no. 3: 383-419.