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Viruses 2009, 1(2), 222-240; doi:10.3390/v1020222
Review

HCV Animal Models: A Journey of More than 30 Years

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Received: 12 June 2009 / Revised: 5 August 2009 / Accepted: 18 August 2009 / Published: 2 September 2009
(This article belongs to the Special Issue Hepatitis Viruses)
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Abstract

In the 1970s and 1980s it became increasingly clear that blood transfusions could induce a form of chronic hepatitis that could not be ascribed to any of the viruses known to cause liver inflammation. In 1989, the hepatitis C virus (HCV) was discovered and found to be the major causative agent of these infections. Because of its narrow ropism, the in vivo study of this virus was, especially in the early days, limited to the chimpanzee. In the past decade, several alternative animal models have been created. In this review we review these novel animal models and their contribution to our current understanding of the biology of HCV.
Keywords: HCV; animal model; chimpanzee; chimeric mice; uPA-SCID; hepatitis C; antiviral therapy; neutralizing antibodies HCV; animal model; chimpanzee; chimeric mice; uPA-SCID; hepatitis C; antiviral therapy; neutralizing antibodies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Meuleman, P.; Leroux-Roels, G. HCV Animal Models: A Journey of More than 30 Years. Viruses 2009, 1, 222-240.

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