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Materials 2016, 9(4), 290; doi:10.3390/ma9040290

SiO2-CaO-P2O5 Bioactive Glasses: A Promising Curcuminoids Delivery System

Department of Chemical and Geological Sciences, University of Modena and Reggio Emilia, Via G. Campi 103, Modena 41125, Italy
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Academic Editor: Aldo R. Boccaccini
Received: 22 March 2016 / Revised: 8 April 2016 / Accepted: 11 April 2016 / Published: 15 April 2016
(This article belongs to the Special Issue Bioactive Glasses)
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Abstract

In this paper, we report the study of the loading and the release of curcuminoids by bioactive glasses (BG) and mesoporous bioactive glasses (MBG). Through a detailed spectroscopic study, it was possible to determine the amount and the type of molecules released in water and in simulated body fluid (SBF). In particular, curcumin and K2T21 show a good ability to be released in di-keto and keto-enolic form, depending from the pH. However, after 24 h, the amount of pristine curcumin release is very low with a consequent increment of degradation products derived by curcuminoids. The presence of –OH groups on curcuminoids is a fundamental pre-requisite in order to obtain a high loading and release in polar solution such as water and SBF. The substrate on which we loaded the drugs does not seem to affect significantly the loading and the release of the drugs. The environment, instead, affects the release: for all the drugs, the release in SBF, buffered at pH of 7.4, is slightly worse than the release in water (basic pH values). View Full-Text
Keywords: bioactive glass; curcuminoids; drug release bioactive glass; curcuminoids; drug release
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nicolini, V.; Caselli, M.; Ferrari, E.; Menabue, L.; Lusvardi, G.; Saladini, M.; Malavasi, G. SiO2-CaO-P2O5 Bioactive Glasses: A Promising Curcuminoids Delivery System. Materials 2016, 9, 290.

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