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Materials 2016, 9(11), 949;

In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration

School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
Graduate Institute of Biomedical Materials & Tissue Engineering, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
Dental Department, Taipei Medical University Hospital, Taipei 110, Taiwan
Department of General Dentistry, Chang Gung Memorial Hospital, Taipei 106, Taiwan
Graduate Institute of Dental and Craniofacial Science, Chang Gung University, Taoyuan 333, Taiwan
Sunmax Biotech Co., Ltd., Tainan 741, Taiwan
Dental Department, Taipei Medical University, Shuang-Ho Hospital, Taipei 235, Taiwan
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Alexandru Mihai Grumezescu
Received: 12 September 2016 / Revised: 5 October 2016 / Accepted: 4 November 2016 / Published: 22 November 2016
(This article belongs to the Special Issue Materials for Hard and Soft Tissue Engineering: Novel Approaches)
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For years, in order to improve bone regeneration and prevent the need of a second stage surgery to remove non-resorbable membranes, biological absorbable membranes have gradually been developed and applied in guided tissue regeneration (GTR). The present study’s main objective was to achieve space maintenance and bone regeneration using a new freeze-dried developed porcine collagen membrane, and compare it with an already commercial collagen membrane, when both were used with a bovine xenograft in prepared alveolar ridge bone defects. Prior to surgery, the membrane’s vitality analysis showed statistically significant higher cell proliferation in the test membrane over the commercial one. In six beagle dogs, commercial bone xenograft was packed in lateral ridge bone defects prepared in the left and right side and then covered with test porcine collagen membrane or commercial collagen membrane. Alveolar height changes were measured. Histomorphometric results, in vitro and in vivo properties indicated that the new porcine collagen membrane is biocompatible, enhances bone xenograft osteoconduction, and reduces the alveolar ridge height reabsorption rate. View Full-Text
Keywords: collagen membrane; alveolar bone; guided bone regeneration; animal study collagen membrane; alveolar bone; guided bone regeneration; animal study

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Salamanca, E.; Tsai, C.-Y.; Pan, Y.-H.; Lin, Y.-T.; Huang, H.-M.; Teng, N.-C.; Lin, C.-T.; Feng, S.-W.; Chang, W.-J. In Vitro and In Vivo Study of a Novel Porcine Collagen Membrane for Guided Bone Regeneration. Materials 2016, 9, 949.

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