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Materials 2015, 8(8), 4733-4750; doi:10.3390/ma8084733

Mineralized Collagen: Rationale, Current Status, and Clinical Applications

1
School of Materials Science and Engineering, Tsinghua University, Haidian District, Beijing 100084, China
2
Beijing Allgens Medical Science and Technology Co., Ltd., No.1 Disheng East Road, Yizhuang Economic and Technological Development Zone, Beijing 100176, China
3
The 401 Hospital of Chinese People's Liberation Army, No. 22 Minjiang Road, Qingdao 266071, China
4
The General Hospital of People's Liberation Army, No. 28 Fuxing Road, Beijing 100853, China
*
Author to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Received: 16 May 2015 / Revised: 29 June 2015 / Accepted: 13 July 2015 / Published: 24 July 2015
(This article belongs to the Special Issue Novel Bone Substitute Materials)
View Full-Text   |   Download PDF [2470 KB, uploaded 24 July 2015]   |  

Abstract

This paper presents a review of the rationale for the in vitro mineralization process, preparation methods, and clinical applications of mineralized collagen. The rationale for natural mineralized collagen and the related mineralization process has been investigated for decades. Based on the understanding of natural mineralized collagen and its formation process, many attempts have been made to prepare biomimetic materials that resemble natural mineralized collagen in both composition and structure. To date, a number of bone substitute materials have been developed based on the principles of mineralized collagen, and some of them have been commercialized and approved by regulatory agencies. The clinical outcomes of mineralized collagen are of significance to advance the evaluation and improvement of related medical device products. Some representative clinical cases have been reported, and there are more clinical applications and long-term follow-ups that currently being performed by many research groups. View Full-Text
Keywords: mineralized collagen; collagen; hydroxyapatite; biomineralization; self-assembly; medical device product; clinical application mineralized collagen; collagen; hydroxyapatite; biomineralization; self-assembly; medical device product; clinical application
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Qiu, Z.-Y.; Cui, Y.; Tao, C.-S.; Zhang, Z.-Q.; Tang, P.-F.; Mao, K.-Y.; Wang, X.-M.; Cui, F.-Z. Mineralized Collagen: Rationale, Current Status, and Clinical Applications. Materials 2015, 8, 4733-4750.

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