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Materials 2015, 8(5), 2523-2536; doi:10.3390/ma8052523

A Novel Porcine Graft for Regeneration of Bone Defects

1
School of Dentistry, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan
2
School of Dental Technology, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan
3
Graduate Institute of Biomedical Materials & Tissue Engineering, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan
4
Dental Department of Taipei Medical University, Shuang-Ho Hospital, Taipei 110, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Received: 31 March 2015 / Revised: 23 April 2015 / Accepted: 29 April 2015 / Published: 12 May 2015
(This article belongs to the Special Issue Novel Bone Substitute Materials)
View Full-Text   |   Download PDF [2262 KB, uploaded 12 May 2015]   |  

Abstract

Bone regeneration procedures require alternative graft biomaterials to those for autogenous bone. Therefore, we developed a novel porcine graft using particle sizes of 250–500 μm and 500–1000 μm in rabbit calvarial bone defects and compared the graft properties with those of commercial hydroxyapatite (HA)/beta-tricalcium phosphate (β-TCP) over eight weeks. Surgery was performed in 20 adult male New Zealand white rabbits. During a standardized surgical procedure, four calvarial critical-size defects of 5 mm diameter and 3 mm depth were prepared. The defects were filled with HA/β-TCP, 250–500 μm or 500–1000 μm porcine graft, and control defects were not filled. The animals were grouped for sacrifice at 1, 2, 4, and 8 weeks post-surgery. Subsequently, sample blocks were prepared for micro-computed tomography (micro-CT) scanning and histological sectioning. Similar bone formations were observed in all three treatment groups, although the 250–500 μm porcine graft performed slightly better. Rabbit calvarial bone tissue positively responded to porcine grafts and commercial HA/β-TCP, structural analyses showed similar crystallinity and porosity of the porcine and HA/β-TCP grafts, which facilitated bone formation through osteoconduction. These porcine grafts can be considered as graft substitutes, although further development is required for clinical applications. View Full-Text
Keywords: bone regeneration; bone graft; porcine tissue; in vivo test; hydroxyapatite bone regeneration; bone graft; porcine tissue; in vivo test; hydroxyapatite
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Salamanca, E.; Lee, W.-F.; Lin, C.-Y.; Huang, H.-M.; Lin, C.-T.; Feng, S.-W.; Chang, W.-J. A Novel Porcine Graft for Regeneration of Bone Defects. Materials 2015, 8, 2523-2536.

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