Materials 2011, 4(2), 339-354; doi:10.3390/ma4020339
Article

A New Highly Bioactive Composite for Scaffold Applications: A Feasibility Study

email, * email and email
Received: 22 December 2010; in revised form: 18 January 2011 / Accepted: 26 January 2011 / Published: 28 January 2011
(This article belongs to the Special Issue Tissue Engineering Scaffolds)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Hydroxyapatite (HA) has been widely investigated as scaffolding material for bone tissue engineering, mainly for its excellent biocompatibility. Presently, there is an increasing interest in the composites of hydroxyapatite with bioactive glasses, with the aim to obtain systems with improved bioactivity or mechanical properties. Moreover, modifying the ratio between bioactive glass and hydroxyapatite results in the possibility of controlling the reaction rate of the composite scaffold in the human body. However, high temperature treatments are usually required in order to sinter HA-based composites, causing the bioactive glass to crystallize into a glass-ceramic, with possible negative effects on its bioactivity. In the present research work, a glass composition belonging to the Na2O-CaO-P2O5-SiO2 system, with a reduced tendency to crystallize, is applied to realize HA-based composites. The novel samples can be sintered at a relative low temperature (750 °C) compared to the widely studied HA/45S5 Bioglass® composites. This fact greatly helps to preserve the amorphous nature of the glass, with excellent effects in terms of bioactivity, according to in vitro tests. As a first application, the obtained composites are also tested to realize highly porous scaffolds by means of the standard burning out method.
Keywords: composites; hydroxyapatite; bioactive glasses; scaffolds
PDF Full-text Download PDF Full-Text [685 KB, uploaded 28 January 2011 12:14 CET]

Export to BibTeX |
EndNote


MDPI and ACS Style

Bellucci, D.; Cannillo, V.; Sola, A. A New Highly Bioactive Composite for Scaffold Applications: A Feasibility Study. Materials 2011, 4, 339-354.

AMA Style

Bellucci D, Cannillo V, Sola A. A New Highly Bioactive Composite for Scaffold Applications: A Feasibility Study. Materials. 2011; 4(2):339-354.

Chicago/Turabian Style

Bellucci, Devis; Cannillo, Valeria; Sola, Antonella. 2011. "A New Highly Bioactive Composite for Scaffold Applications: A Feasibility Study." Materials 4, no. 2: 339-354.

Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert