Materials 2011, 4(3), 527-542; doi:10.3390/ma4030527

Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering

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Received: 17 January 2011; Accepted: 25 February 2011 / Published: 1 March 2011
(This article belongs to the Special Issue Tissue Engineering Scaffolds)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This research activity was aimed at the development of dual-scale scaffolds consisting of three-dimensional constructs of aligned poly(ε-caprolactone) (PCL) microfilaments and electrospun poly(lactic-co-glycolic acid) (PLGA) fibers. PCL constructs composed by layers of parallel microsized filaments (0/90° lay-down pattern), with a diameter of around 365 μm and interfilament distance of around 191 μm, were produced using a melt extrusion-based additive manufacturing technique. PLGA electrospun fibers with a diameter of around 1 μm were collected on top of the PCL constructs with different thicknesses, showing a certain degree of alignment. Cell culture experiments employing the MC3T3 murine preosteoblast cell line showed good cell viability and adhesion on the dual-scale scaffolds. In particular, the influence of electrospun fibers on cell morphology and behavior was evident, as well as in creating a structural bridging for cell colonization in the interfilament gap.
Keywords: additive manufacturing; electrospinning; scaffold; tissue engineering
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MDPI and ACS Style

Mota, C.; Puppi, D.; Dinucci, D.; Errico, C.; Bártolo, P.; Chiellini, F. Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering. Materials 2011, 4, 527-542.

AMA Style

Mota C, Puppi D, Dinucci D, Errico C, Bártolo P, Chiellini F. Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering. Materials. 2011; 4(3):527-542.

Chicago/Turabian Style

Mota, Carlos; Puppi, Dario; Dinucci, Dinuccio; Errico, Cesare; Bártolo, Paulo; Chiellini, Federica. 2011. "Dual-Scale Polymeric Constructs as Scaffolds for Tissue Engineering." Materials 4, no. 3: 527-542.

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