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Laser Fabrication of 3D Gelatin Scaffolds for the Generation of Bioartificial Tissues
Department of Nanotechnology, Laser Zentrum Hannover e.V., Hollerithallee 8, D-30419 Hannover, Germany
Polymer Chemistry & Biomaterials Research Group, University of Ghent, Krijgslaan 281, Building S4-Bis, 9000 Ghent, Belgium
Department of Cardiac-, Thoraic-, Transplantation-, and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany
* Author to whom correspondence should be addressed.
Received: 1 December 2010; in revised form: 6 January 2011 / Accepted: 12 January 2011 / Published: 19 January 2011
Abstract: In the present work, the two-photon polymerization (2PP) technique was applied to develop precisely defined biodegradable 3D tissue engineering scaffolds. The scaffolds were fabricated via photopolymerization of gelatin modified with methacrylamide moieties. The results indicate that the gelatin derivative (GelMod) preserves its enzymatic degradation capability after photopolymerization. In addition, the developed scaffolds using 2PP support primary adipose-derived stem cell (ASC) adhesion, proliferation and differentiation into the anticipated lineage.
Keywords: scaffolds; computer-aided design; laser fabrication; two-photon polymerization; gelatin; tissue engineering; biodegradation; stem cells; adipose tissue
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Ovsianikov, A.; Deiwick, A.; Van Vlierberghe, S.; Pflaum, M.; Wilhelmi, M.; Dubruel, P.; Chichkov, B. Laser Fabrication of 3D Gelatin Scaffolds for the Generation of Bioartificial Tissues. Materials 2011, 4, 288-299.
Ovsianikov A, Deiwick A, Van Vlierberghe S, Pflaum M, Wilhelmi M, Dubruel P, Chichkov B. Laser Fabrication of 3D Gelatin Scaffolds for the Generation of Bioartificial Tissues. Materials. 2011; 4(1):288-299.
Ovsianikov, Aleksandr; Deiwick, Andrea; Van Vlierberghe, Sandra; Pflaum, Michael; Wilhelmi, Mathias; Dubruel, Peter; Chichkov, Boris. 2011. "Laser Fabrication of 3D Gelatin Scaffolds for the Generation of Bioartificial Tissues." Materials 4, no. 1: 288-299.