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Materials 2010, 3(7), 4051-4065; doi:10.3390/ma3074051
Article

Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery

1
, 2
 and 1,*
Received: 20 May 2010; Accepted: 1 July 2010 / Published: 13 July 2010
(This article belongs to the Special Issue Magnetic Nanoparticles)
Download PDF [620 KB, updated 14 July 2010; original version uploaded 13 July 2010]
Abstract: Multifunctional nanoparticles composed of MnFe2O4 were encapsulated in chitosan for investigation of system to combine magnetically-triggered drug delivery and localized hyperthermia for cancer treatment with the previously published capacity of MnFe2O4 to be used as an efficient MRI contrast agent for cancer diagnosis. This paper focuses on the synthesis and characterization of magnetic MnFe2O4 nanoparticles, their dispersion in water and their incorporation in chitosan, which serves as a drug carrier. The surface of the MnFe2O4 nanoparticles was modified with meso-2,3-di-mercaptosuccinic acid (DMSA) to develop stable aqueous dispersions. The nanoparticles were coated with chitosan, and the magnetic properties, heat generation and hydrodynamic size of chitosan-coated MnFe2O4 were evaluated for various linker concentrations and in a range of pH conditions.
Keywords: multifunctional magnetic nanoparticles; chitosan; MnFe2O4 nanoparticles; magnetic hyperthermia; drug delivery multifunctional magnetic nanoparticles; chitosan; MnFe2O4 nanoparticles; magnetic hyperthermia; drug delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, D.-H.; Nikles, D.E.; Brazel, C.S. Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery. Materials 2010, 3, 4051-4065.

AMA Style

Kim D-H, Nikles DE, Brazel CS. Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery. Materials. 2010; 3(7):4051-4065.

Chicago/Turabian Style

Kim, Dong-Hyun; Nikles, David E.; Brazel, Christopher S. 2010. "Synthesis and Characterization of Multifunctional Chitosan- MnFe2O4 Nanoparticles for Magnetic Hyperthermia and Drug Delivery." Materials 3, no. 7: 4051-4065.


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