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Int. J. Mol. Sci. 2010, 11(8), 2910-2920; doi:10.3390/ijms11082910

Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique

Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
* Author to whom correspondence should be addressed.
Received: 22 April 2010 / Revised: 26 July 2010 / Accepted: 2 August 2010 / Published: 10 August 2010
(This article belongs to the Special Issue Magnetic Nanoparticles)
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Here we applied a magnetic force-based tissue engineering technique to cardiac tissue fabrication. A mixture of extracellular matrix precursor and cardiomyocytes labeled with magnetic nanoparticles was added into a well containing a central polycarbonate cylinder. With the use of a magnet, the cells were attracted to the bottom of the well and allowed to form a cell layer. During cultivation, the cell layer shrank towards the cylinder, leading to the formation of a ring-shaped tissue that possessed a multilayered cell structure and contractile properties. These results indicate that magnetic tissue fabrication is a promising approach for cardiac tissue engineering.
Keywords: cardiac tissue engineering; cardiomyocytes; magnetic nanoparticle; magnetic force cardiac tissue engineering; cardiomyocytes; magnetic nanoparticle; magnetic force
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Akiyama, H.; Ito, A.; Sato, M.; Kawabe, Y.; Kamihira, M. Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique. Int. J. Mol. Sci. 2010, 11, 2910-2920.

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