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Int. J. Mol. Sci. 2010, 11(4), 1759-1776; doi:10.3390/ijms11041759

Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging

Department of Chemistry, Imperial College Genetic Therapies Centre, Imperial College London, Flowers Building, Armstrong Road, London, SW7 2AZ, UK
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Author to whom correspondence should be addressed.
Received: 4 March 2010 / Revised: 6 April 2010 / Accepted: 8 April 2010 / Published: 15 April 2010
(This article belongs to the Special Issue Magnetic Nanoparticles)
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Abstract

In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal imaging neutral nanoparticles for in vivo imaging applications. We discuss the development of such systems and show how paramagnetic liposomes and imaging nanoparticles could be developed as platforms for future multi-functional, multi-modal imaging theranostic nanodevices tailor-made for the combined imaging of early stage disease pathology and functional drug delivery. View Full-Text
Keywords: cellular labeling; liposomes; Gadolinium; paramagnetic liposomes; bimodal liposomes; cellular imaging; tumour imaging; MRI; MRI contrast agents; nanoparticles; magnetic nanoparticles cellular labeling; liposomes; Gadolinium; paramagnetic liposomes; bimodal liposomes; cellular imaging; tumour imaging; MRI; MRI contrast agents; nanoparticles; magnetic nanoparticles
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kamaly, N.; Miller, A.D. Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging. Int. J. Mol. Sci. 2010, 11, 1759-1776.

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