Next Article in Journal
Extraction of Biomolecules Using Phosphonium-Based Ionic Liquids + K3PO4 Aqueous Biphasic Systems
Next Article in Special Issue
Construction of Cardiac Tissue Rings Using a Magnetic Tissue Fabrication Technique
Previous Article in Journal
Engineering Cofactor Preference of Ketone Reducing Biocatalysts: A Mutagenesis Study on a γ-Diketone Reductase from the Yeast Saccharomyces cerevisiae Serving as an Example
Previous Article in Special Issue
Stem Cell Tracking by Nanotechnologies
Int. J. Mol. Sci. 2010, 11(4), 1759-1776; doi:10.3390/ijms11041759
Review

Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging

 and *
Department of Chemistry, Imperial College Genetic Therapies Centre, Imperial College London, Flowers Building, Armstrong Road, London, SW7 2AZ, UK
* Author to whom correspondence should be addressed.
Received: 4 March 2010 / Revised: 6 April 2010 / Accepted: 8 April 2010 / Published: 15 April 2010
(This article belongs to the Special Issue Magnetic Nanoparticles)
View Full-Text   |   Download PDF [367 KB, uploaded 19 June 2014]   |   Browse Figures

Abstract

In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal imaging neutral nanoparticles for in vivo imaging applications. We discuss the development of such systems and show how paramagnetic liposomes and imaging nanoparticles could be developed as platforms for future multi-functional, multi-modal imaging theranostic nanodevices tailor-made for the combined imaging of early stage disease pathology and functional drug delivery.
Keywords: cellular labeling; liposomes; Gadolinium; paramagnetic liposomes; bimodal liposomes; cellular imaging; tumour imaging; MRI; MRI contrast agents; nanoparticles; magnetic nanoparticles cellular labeling; liposomes; Gadolinium; paramagnetic liposomes; bimodal liposomes; cellular imaging; tumour imaging; MRI; MRI contrast agents; nanoparticles; magnetic nanoparticles
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Kamaly, N.; Miller, A.D. Paramagnetic Liposome Nanoparticles for Cellular and Tumour Imaging. Int. J. Mol. Sci. 2010, 11, 1759-1776.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert