Next Article in Journal
End-Grafted Polymer Chains onto Inorganic Nano-Objects
Next Article in Special Issue
Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering
Previous Article in Journal
Freeze-Casting of Porous Biomaterials: Structure, Properties and Opportunities
Previous Article in Special Issue
Collagen-Based Biomaterials for Tissue Engineering Applications
Article Menu

Article Versions

Export Article

Open AccessReview
Materials 2010, 3(3), 1928-1980; doi:10.3390/ma3031928

Targeted Delivery of Protein Drugs by Nanocarriers

Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126, Pisa, Italy
*
Author to whom correspondence should be addressed.
Received: 28 December 2009 / Revised: 16 February 2010 / Accepted: 15 March 2010 / Published: 17 March 2010
(This article belongs to the Special Issue Advances in Biomaterials)
View Full-Text   |   Download PDF [4132 KB, uploaded 17 March 2010]   |  

Abstract

Recent advances in biotechnology demonstrate that peptides and proteins are the basis of a new generation of drugs. However, the transportation of protein drugs in the body is limited by their high molecular weight, which prevents the crossing of tissue barriers, and by their short lifetime due to immuno response and enzymatic degradation. Moreover, the ability to selectively deliver drugs to target organs, tissues or cells is a major challenge in the treatment of several human diseases, including cancer. Indeed, targeted delivery can be much more efficient than systemic application, while improving bioavailability and limiting undesirable side effects. This review describes how the use of targeted nanocarriers such as nanoparticles and liposomes can improve the pharmacokinetic properties of protein drugs, thus increasing their safety and maximizing the therapeutic effect. View Full-Text
Keywords: nanocarrier; targeted delivery; protein drug nanocarrier; targeted delivery; protein drug
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Solaro, R.; Chiellini, F.; Battisti, A. Targeted Delivery of Protein Drugs by Nanocarriers. Materials 2010, 3, 1928-1980.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top