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Targeted Delivery of Protein Drugs by Nanocarriers
Department of Chemistry and Industrial Chemistry, University of Pisa, Via Risorgimento 35, 56126, Pisa, Italy
* Author to whom correspondence should be addressed.
Received: 28 December 2009; in revised form: 16 February 2010 / Accepted: 15 March 2010 / Published: 17 March 2010
Abstract: Recent advances in biotechnology demonstrate that peptides and proteins are the basis of a new generation of drugs. However, the transportation of protein drugs in the body is limited by their high molecular weight, which prevents the crossing of tissue barriers, and by their short lifetime due to immuno response and enzymatic degradation. Moreover, the ability to selectively deliver drugs to target organs, tissues or cells is a major challenge in the treatment of several human diseases, including cancer. Indeed, targeted delivery can be much more efficient than systemic application, while improving bioavailability and limiting undesirable side effects. This review describes how the use of targeted nanocarriers such as nanoparticles and liposomes can improve the pharmacokinetic properties of protein drugs, thus increasing their safety and maximizing the therapeutic effect.
Keywords: nanocarrier; targeted delivery; protein drug
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Solaro, R.; Chiellini, F.; Battisti, A. Targeted Delivery of Protein Drugs by Nanocarriers. Materials 2010, 3, 1928-1980.
Solaro R, Chiellini F, Battisti A. Targeted Delivery of Protein Drugs by Nanocarriers. Materials. 2010; 3(3):1928-1980.
Solaro, Roberto; Chiellini, Federica; Battisti, Antonella. 2010. "Targeted Delivery of Protein Drugs by Nanocarriers." Materials 3, no. 3: 1928-1980.