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Materials 2010, 3(3), 1863-1887; doi:10.3390/ma3031863

Collagen-Based Biomaterials for Tissue Engineering Applications

1 Laboratoire d’Organogénèse Expérimentale (LOEX), Centre de recherche FRSQ du CHA universitaire de Québec, Hôpital du Saint-Sacrement, Québec, QC, G1S 4L8 Canada 2 Département de chirurgie, Faculté de médecine, Université Laval, Québec, QC, G1V 0A6 Canada
* Author to whom correspondence should be addressed.
Received: 2 February 2010 / Revised: 9 March 2010 / Accepted: 11 March 2010 / Published: 16 March 2010
(This article belongs to the Special Issue Advances in Biomaterials)
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Collagen is the most widely distributed class of proteins in the human body. The use of collagen-based biomaterials in the field of tissue engineering applications has been intensively growing over the past decades. Multiple cross-linking methods were investigated and different combinations with other biopolymers were explored in order to improve tissue function. Collagen possesses a major advantage in being biodegradable, biocompatible, easily available and highly versatile. However, since collagen is a protein, it remains difficult to sterilize without alterations to its structure. This review presents a comprehensive overview of the various applications of collagen-based biomaterials developed for tissue engineering, aimed at providing a functional material for use in regenerative medicine from the laboratory bench to the patient bedside.
Keywords: collagen; biomaterial; soft tissue collagen; biomaterial; soft tissue
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Parenteau-Bareil, R.; Gauvin, R.; Berthod, F. Collagen-Based Biomaterials for Tissue Engineering Applications. Materials 2010, 3, 1863-1887.

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