Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Int. J. Environ. Res. Public Health 2012, 9(5), 1939-1953; doi:10.3390/ijerph9051939
Article

The Aryl Hydrocarbon Receptor Pathway: A Key Component of the microRNA-Mediated AML Signalisome

1
 and 1,2,*
Received: 21 March 2012; in revised form: 27 April 2012 / Accepted: 8 May 2012 / Published: 18 May 2012
View Full-Text   |   Download PDF [429 KB, uploaded 19 June 2014]   |   Browse Figures
Abstract: Recent research has spotlighted the role of microRNAs (miRNAs) as critical epigenetic regulators of hematopoietic stem cell differentiation and leukemia development. Despite the recent advances in knowledge surrounding epigenetics and leukemia, the mechanisms underlying miRNAs’ influence on leukemia development have yet to be clearly elucidated. Our aim was to identify high ranking biological pathways altered at the gene expression level and under epigenetic control. Specifically, we set out to test the hypothesis that miRNAs dysregulated in acute myeloid leukemia (AML) converge on a common pathway that can influence signaling related to hematopoiesis and leukemia development. We identified genes altered in AML patients that are under common regulation of seven key miRNAs. By mapping these genes to a global interaction network, we identified the “AML Signalisome”. The AML Signalisome comprises 53 AML-associated molecules, and is enriched for proteins that play a role in the aryl hydrocarbon receptor (AhR) pathway, a major regulator of hematopoiesis. Furthermore, we show biological enrichment for hematopoiesis-related proteins within the AML Signalisome. These findings provide important insight into miRNA-regulated pathways in leukemia, and may help to prioritize targets for disease prevention and treatment.
Keywords: aryl hydrocarbon receptor; gene expression; leukemia; microRNA; systems biology aryl hydrocarbon receptor; gene expression; leukemia; microRNA; systems biology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Rager, J.E.; Fry, R.C. The Aryl Hydrocarbon Receptor Pathway: A Key Component of the microRNA-Mediated AML Signalisome. Int. J. Environ. Res. Public Health 2012, 9, 1939-1953.

AMA Style

Rager JE, Fry RC. The Aryl Hydrocarbon Receptor Pathway: A Key Component of the microRNA-Mediated AML Signalisome. International Journal of Environmental Research and Public Health. 2012; 9(5):1939-1953.

Chicago/Turabian Style

Rager, Julia E.; Fry, Rebecca C. 2012. "The Aryl Hydrocarbon Receptor Pathway: A Key Component of the microRNA-Mediated AML Signalisome." Int. J. Environ. Res. Public Health 9, no. 5: 1939-1953.



Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert