Special Issue "Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs"

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A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).

Deadline for manuscript submissions: closed (31 March 2012)

Special Issue Editor

Guest Editor
Dr. Luoping Zhang
Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
Website: http://sph.berkeley.edu/faculty/zhang.php
E-Mail: luoping@berkeley.edu
Phone: +1 510 643 5189
Fax: +1 510 642 0427
Interests: the impact and mechanisms of exposures to toxic chemicals on human health, particularly in carcinogenesis and leukemogenesis; application of omic technologies in molecular epidemiological studies; and the development of new tools and assays to explore relevant biomakers

Special Issue Information

Dear Colleagues,

The etiology of the blood cancer leukemia is still largely unknown; however, exposures to toxic chemicals and cancer-therapeutic drugs can cause leukemia in adults and children. Benzene is a well established leukemogen and occupational exposure to formaldehyde has recently been shown to increase leukemia risk. Additionally, a portion of primary cancer patients develop acute myeloid leukemia (AML) after treatment with chemotherapeutic drugs, such as alkylating agents (melphalan etc) and DNA topoisomerase II (Topo II) inhibitors (etoposide etc.). Evidence suggests that the leukemia associated with exposure to different types of leukemogen exhibits specific molecular changes. For instance, therapy-related AML resulting from treatment with alkylating agents is mainly associated with loss of chromosomes 5 and 7, while Topo II inhibitor-induced AML is commonly associated with chromosomal translocations. Although chromosomal aneuploidy and rearrangements are hallmarks of leukemia, it is not well understood how these chemicals interact with normal hematopoietic stem/progenitor cells and disrupt bone marrow niches. This special issue will focus on molecular (genetic and epigenetic) mechanisms of chemically-induced leukmogenesis in exposed humans, experimental animal models and in vitro systems. We will accept original research reports, short communications/commentaries, and limited review papers deemed relevant.

Dr. Luoping Zhang
Guest Editor

Keywords

  • Leukemogenesis
  • Leukemogen
  • Benzene
  • Formaldehyde
  • Therapy-related leukemia
  • Alkylating agents
  • DNA topoisomerase II inhibitors
  • Mechanisms

Published Papers (7 papers)

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Displaying article 1-7
p. 2875-2893
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Int. J. Environ. Res. Public Health 2012, 9(8), 2875-2893; doi:10.3390/ijerph9082875
Received: 14 June 2012; in revised form: 5 July 2012 / Accepted: 7 August 2012 / Published: 14 August 2012
Show/Hide Abstract | Cited by 11 | PDF Full-text (211 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs)
p. 2788-2800
by , , , , ,  and
Int. J. Environ. Res. Public Health 2012, 9(8), 2788-2800; doi:10.3390/ijerph9082788
Received: 12 June 2012; in revised form: 25 July 2012 / Accepted: 31 July 2012 / Published: 3 August 2012
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(This article belongs to the Special Issue Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs)
p. 2636-2657
by ,  and
Int. J. Environ. Res. Public Health 2012, 9(8), 2636-2657; doi:10.3390/ijerph9082636
Received: 23 May 2012; in revised form: 12 June 2012 / Accepted: 2 July 2012 / Published: 27 July 2012
Show/Hide Abstract | Cited by 3 | PDF Full-text (322 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs)
p. 2479-2503
by , ,  and
Int. J. Environ. Res. Public Health 2012, 9(7), 2479-2503; doi:10.3390/ijerph9072479
Received: 18 May 2012; in revised form: 25 June 2012 / Accepted: 26 June 2012 / Published: 12 July 2012
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(This article belongs to the Special Issue Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs)
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p. 2444-2453
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Int. J. Environ. Res. Public Health 2012, 9(7), 2444-2453; doi:10.3390/ijerph9072444
Received: 16 May 2012; in revised form: 27 June 2012 / Accepted: 28 June 2012 / Published: 10 July 2012
Show/Hide Abstract | Cited by 13 | PDF Full-text (112 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs)
p. 2075-2091
by  and
Int. J. Environ. Res. Public Health 2012, 9(6), 2075-2091; doi:10.3390/ijerph9062075
Received: 2 May 2012; in revised form: 23 May 2012 / Accepted: 29 May 2012 / Published: 31 May 2012
Show/Hide Abstract | Cited by 11 | PDF Full-text (426 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs)
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p. 1939-1953
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Int. J. Environ. Res. Public Health 2012, 9(5), 1939-1953; doi:10.3390/ijerph9051939
Received: 21 March 2012; in revised form: 27 April 2012 / Accepted: 8 May 2012 / Published: 18 May 2012
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(This article belongs to the Special Issue Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs)
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Last update: 25 February 2014

Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert