Special Issue "Leukemia Arising from Chemical Exposures and Chemotherapeutic Drugs"
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601).
Deadline for manuscript submissions: closed (31 March 2012)
Dr. Luoping Zhang
Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
Phone: +1 510 643 5189
Fax: +1 510 642 0427
Interests: the impact and mechanisms of exposures to toxic chemicals on human health, particularly in carcinogenesis and leukemogenesis; application of omic technologies in molecular epidemiological studies; and the development of new tools and assays to explore relevant biomakers
The etiology of the blood cancer leukemia is still largely unknown; however, exposures to toxic chemicals and cancer-therapeutic drugs can cause leukemia in adults and children. Benzene is a well established leukemogen and occupational exposure to formaldehyde has recently been shown to increase leukemia risk. Additionally, a portion of primary cancer patients develop acute myeloid leukemia (AML) after treatment with chemotherapeutic drugs, such as alkylating agents (melphalan etc) and DNA topoisomerase II (Topo II) inhibitors (etoposide etc.). Evidence suggests that the leukemia associated with exposure to different types of leukemogen exhibits specific molecular changes. For instance, therapy-related AML resulting from treatment with alkylating agents is mainly associated with loss of chromosomes 5 and 7, while Topo II inhibitor-induced AML is commonly associated with chromosomal translocations. Although chromosomal aneuploidy and rearrangements are hallmarks of leukemia, it is not well understood how these chemicals interact with normal hematopoietic stem/progenitor cells and disrupt bone marrow niches. This special issue will focus on molecular (genetic and epigenetic) mechanisms of chemically-induced leukmogenesis in exposed humans, experimental animal models and in vitro systems. We will accept original research reports, short communications/commentaries, and limited review papers deemed relevant.
Dr. Luoping Zhang
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed Open Access monthly journal published by MDPI.
- Therapy-related leukemia
- Alkylating agents
- DNA topoisomerase II inhibitors
Article: The Aryl Hydrocarbon Receptor Pathway: A Key Component of the microRNA-Mediated AML Signalisome
Int. J. Environ. Res. Public Health 2012, 9(5), 1939-1953; doi:10.3390/ijerph9051939
Received: 21 March 2012; in revised form: 27 April 2012 / Accepted: 8 May 2012 / Published: 18 May 2012| Download PDF Full-text (429 KB) | Download XML Full-text |
Review: Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents
Int. J. Environ. Res. Public Health 2012, 9(6), 2075-2091; doi:10.3390/ijerph9062075
Received: 2 May 2012; in revised form: 23 May 2012 / Accepted: 29 May 2012 / Published: 31 May 2012| Download PDF Full-text (426 KB) | Download XML Full-text
Review: Secondary Leukemia Associated with the Anti-Cancer Agent, Etoposide, a Topoisomerase II Inhibitor
Int. J. Environ. Res. Public Health 2012, 9(7), 2444-2453; doi:10.3390/ijerph9072444
Received: 16 May 2012; in revised form: 27 June 2012 / Accepted: 28 June 2012 / Published: 10 July 2012| Download PDF Full-text (112 KB) | Download XML Full-text
Int. J. Environ. Res. Public Health 2012, 9(7), 2479-2503; doi:10.3390/ijerph9072479
Received: 18 May 2012; in revised form: 25 June 2012 / Accepted: 26 June 2012 / Published: 12 July 2012| Download PDF Full-text (2510 KB) | Download XML Full-text |
Review: DNA Damage and Repair in Human Cancer: Molecular Mechanisms and Contribution to Therapy-Related Leukemias
Int. J. Environ. Res. Public Health 2012, 9(8), 2636-2657; doi:10.3390/ijerph9082636
Received: 23 May 2012; in revised form: 12 June 2012 / Accepted: 2 July 2012 / Published: 27 July 2012| Download PDF Full-text (322 KB) | Download XML Full-text
Article: Over-Expression of CYP2E1 mRNA and Protein: Implications of Xenobiotic Induced Damage in Patients with De Novo Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFβ-MYH11
Int. J. Environ. Res. Public Health 2012, 9(8), 2788-2800; doi:10.3390/ijerph9082788
Received: 12 June 2012; in revised form: 25 July 2012 / Accepted: 31 July 2012 / Published: 3 August 2012| Download PDF Full-text (430 KB) | Download XML Full-text
Review: Leukemia and Benzene
Int. J. Environ. Res. Public Health 2012, 9(8), 2875-2893; doi:10.3390/ijerph9082875
Received: 14 June 2012; in revised form: 5 July 2012 / Accepted: 7 August 2012 / Published: 14 August 2012| Download PDF Full-text (211 KB) | Download XML Full-text
Type of Paper: Article
Title: The Aryl Hydrocarbon Receptor Pathway: A Key Component of the miRNA-Mediated AML Signalisome
Auhtors: Julia E. Rager1 and Rebecca C. Fry1,2
Affiliation: 1 Department of Environmental Sciences and Engineering, Gillings School of Global Public Health
2 Curriculum in Toxicology, University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, USA
Abstract: Recent research has spotlighted the role of microRNAs (miRNAs) as critical epigenetic regulators of hematopoietic stem cell differentiation and leukemia development. Despite the recent advances in knowledge surrounding epigenetics and leukemia, the mechanisms underlying miRNAs’ influence on leukemia development have yet to be clearly elucidated. Our aim was to identify high ranking biological pathways altered at the gene expression level and under epigenetic control. Specifically, we set out to test the hypothesis that miRNAs dysregulated in acute myeloid leukemia (AML) converge on a common pathway that can influence signaling related to hematopoiesis and leukemia development. We identified genes altered in AML patients that are under common regulation of seven key miRNAs. By mapping these genes to a global interaction network, we identified the “AML Signalisome”. The AML Signalisome comprises 53 AML-associated molecules, and is enriched for proteins that play a role in the aryl hydrocarbon receptor (AhR) pathway, a major regulator of hematopoiesis. Furthermore, we show biological enrichment for hematopoiesis-related proteins within the AML Signalisome. These findings provide insight into the pathophysiological mechanisms underlying leukemogenesis, and may help to prioritize targeted pathways for disease prevention and treatment.
Keywords: aryl hydrocarbon receptor; gene expression; leukemia; microRNA; systems biology
Last update: 3 January 2013