Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Int. J. Environ. Res. Public Health 2010, 7(7), 2745-2788; doi:10.3390/ijerph7072745
Review

Chelation in Metal Intoxication

*  and
Received: 8 March 2010; in revised form: 22 April 2010 / Accepted: 27 May 2010 / Published: 28 June 2010
(This article belongs to the Special Issue Heavy Metals and Health)
View Full-Text   |   Download PDF [530 KB, uploaded 19 June 2014]
Abstract: Chelation therapy is the preferred medical treatment for reducing the toxic effects of metals. Chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. 2,3-Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, however its serious side effects have led researchers to develop less toxic analogues. Hydrophilic chelators like meso-2,3-dimercaptosuccinic acid effectively promote renal metal excretion, but their ability to access intracellular metals is weak. Newer strategies to address these drawbacks like combination therapy (use of structurally different chelating agents) or co-administration of antioxidants have been reported recently. In this review we provide an update of the existing chelating agents and the various strategies available for the treatment of heavy metals and metalloid intoxications.
Keywords: chelating agents; combination therapy; oxidative stress; antioxidant; succimer; monoesters; heavy metals chelating agents; combination therapy; oxidative stress; antioxidant; succimer; monoesters; heavy metals
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Flora, S.J.; Pachauri, V. Chelation in Metal Intoxication. Int. J. Environ. Res. Public Health 2010, 7, 2745-2788.

AMA Style

Flora SJ, Pachauri V. Chelation in Metal Intoxication. International Journal of Environmental Research and Public Health. 2010; 7(7):2745-2788.

Chicago/Turabian Style

Flora, Swaran J.S.; Pachauri, Vidhu. 2010. "Chelation in Metal Intoxication." Int. J. Environ. Res. Public Health 7, no. 7: 2745-2788.


Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert