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Int. J. Environ. Res. Public Health 2009, 6(10), 2526-2533; doi:10.3390/ijerph6102526
Article

Epidemiological Study of Rickettsial Infections in Patients with Hypertransaminemia in Madrid (Spain)

1,* , 1,2
,
1
,
1,2
 and
1
1 Department of Microbiology and Parasitology, Faculty of Medicine, University of Alcalá, Ctra. Madrid-Barcelona Km 33.6, Alcalá de Henares 28871, Spain 2 Department of Microbiology, Hospital “Príncipe de Asturias”, Ctra. Madrid-Barcelona Km 33.6, Alcalá de Henares 28871, Spain
* Author to whom correspondence should be addressed.
Received: 19 August 2009 / Accepted: 23 September 2009 / Published: 28 September 2009
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Abstract

A retrospective analysis was performed to detect anti-rickettsial antibodies in the serum of patients with hypertransaminemia of unknown etiology, and in that of healthy members of the general population of Madrid (Spain). Among 143 patients 16 (11.2%) were positive for anti-R. conorii IgG antibodies and 7% for R. typhi. PCR analysis was performed in patients with IgM antibodies. Among 143 healthy subjects from the general population, seven (4.9%) were positive for anti-R. conorii IgG antibodies, and 2.8% for R. typhi. These results show that anti-rickettsial antibodies are more commonly detected in patients with hypertransaminemia than in healthy people.
Keywords: Rickettsiae; hypertransaminemia; liver dysfunction; prevalence; Spain Rickettsiae; hypertransaminemia; liver dysfunction; prevalence; Spain
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Lledó, L.; González, R.; Gegúndez, M.I.; Beltrán, M.; Saz, J.V. Epidemiological Study of Rickettsial Infections in Patients with Hypertransaminemia in Madrid (Spain). Int. J. Environ. Res. Public Health 2009, 6, 2526-2533.

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