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Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review
Department of Internal Medicine, SS Annunziata Hospital, Cento (Ferrara), Italy
-“G. Fontana” Centre for the Study and Multidisciplinary Treatment of Alcohol Addiction, Department of Clinical Medicine, University of Bologna, Italy
Vincent P. Dole Dual Diagnosis Unit, Santa Chiara University Hospital, Department of Psychiatry, NPB, University of Pisa, Italy
* Author to whom correspondence should be addressed.
Received: 15 May 2009; Accepted: 21 June 2009 / Published: 24 June 2009
Abstract: Gamma-hydroxybutyric acid (GHB) is a short-chain fatty acid structurally similar to the inhibitory neurotransmitter γ-aminobutyric acid. Clinical trials have demonstrated that 50-100 mg/kg of GHB fractioned into three or six daily doses is able to suppress alcohol withdrawal symptoms and facilitates the maintenance of abstinence from alcohol. These studies have also shown that GHB craving episodes are a very limited phenomenon (about 10-15%). Thus, physicians with access should consider the clinical efficacy of GHB as a valid pharmacological tool for the treatment of alcohol addiction.
Keywords: gamma-hydroxybutyric acid; alcohol withdrawal syndrome; anti-craving drug
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MDPI and ACS Style
Caputo, F.; Vignoli, T.; Maremmani, I.; Bernardi, M.; Zoli, G. Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review. Int. J. Environ. Res. Public Health 2009, 6, 1917-1929.
Caputo F, Vignoli T, Maremmani I, Bernardi M, Zoli G. Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review. International Journal of Environmental Research and Public Health. 2009; 6(6):1917-1929.
Caputo, Fabio; Vignoli, Teo; Maremmani, Icro; Bernardi, Mauro; Zoli, Giorgio. 2009. "Gamma Hydroxybutyric Acid (GHB) for the Treatment of Alcohol Dependence: A Review." Int. J. Environ. Res. Public Health 6, no. 6: 1917-1929.